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Table 1 Baseline characteristics in cancer patients who underwent pericardial window for non-malignant and malignant pericardial effusions

From: Persistent PR segment change in malignant pericardial disease

 

Non-malignant effusion, n = 18 (%)

Malignant effusion, n = 8 (%)

p-value

Age (years)

57.94 [19, 71]

54 [30, 69]

0.27

Male

11 (61.1)

3 (37.5)

0.40

Malignancy

   

 Lung

8 (44.4)

5 (62.5)

0.67

 Breast

1 (5.56)

1 (12.5)

0.53

 Leukemia

5 (27.8)

0 (0)

0.28

 Hodgkin’s

3 (16.7)

0 (0)

0.53

 Head & Neck

0 (0)

1 (12.5)

0.31

 Myelodysplastic Syndrome

1 (5.56)

0 (0)

1.00

 Other

2 (11.1)

1 (12.5)

1.00

Treatment

   

 Chemotherapy

16 (88.9)

7 (87.5)

1.00

 Chemotherapy +

6 (33.3)

1 (12.5)

0.37

 Chest Radiation

 Bone Marrow Transplant

3 (16.7)

0 (0)

0.53

Co-morbidities

   

 Hypertension

8 (44.4)

2 (25)

1.00

 Dyslipidemia

7 (38.9)

1 (12.5)

0.36

 Coronary Artery Disease

2 (11.1)

0 (0)

1.00

 Pulmonary Embolism

3 (16.7)

3 (37.5)

0.33

 Diabetes Mellitus

7 (38.9)

0 (0)

0.06

 Paroxysmal Atrial Fibrillation

7 (38.9)

1 (12.5)

0.36

 History of myopericarditis

1 (5.56)

3 (37.5)

0.07

 Chronic obstructive pulmonary disease

3 (16.7)

1 (12.5)

1.00

 Sepsis

2 (11.1)

0 (0)

1.00

 Connective Tissue Disease

1 (5.56)

1 (12.5)

0.53

 Chronic Kidney Disease

1 (5.56)

0 (0)

1.00

 Other infection

1 (5.56)

0 (0)

1.00

Indication

  

1.00

 Cardiac tamponade

10 (55.6)

7 (87.5)

0.19

 Impending cardiac tamponade

8 (44.4)

1 (12.5)

0.19

 Pericardial effusion

3 (16.7)

0 (0)

0.53

Heart rate (beats per minute)

101 [76, 128]

108 [88, 128]

0.25

ECG

  

<0.001

 Positive*

0 (0)

8 (100)

 

 Negative**

18 (100)

0 (0)

 

Pathology

  

<0.001

 Positive

0 (0)

8 (100)

 

 Negative

18 (100)

0 (0)

 
  1. Baseline characteristics including age, sex, underlying malignancy, treatment course, co-morbidities, indication for pericardial window, heart rates calculated by ECGs, ECG findings and pericardial pathology are compared between cancer patients with non-malignant and malignant pericardial disease. *Positive ECG findings are defined as PR depression in leads I, II and/or aVF and PR elevation in aVR/V1. **Negative ECG findings are defined as isoelectric PR segments. Positive pathology is defined as positive pericardial fluid cytology, biopsy and/or flow cytometry for malignancy. T-tests were used to compare continuous variables with a normal distribution, Wilcoxon rank sum tests were used to compare continuous variables with a non-normal distribution, and Fisher’s exact tests were used to compare categorical variables. A p-value <0.05 was considered statistically significant