Fig. 5

Mechanisms by which anti-neoplastic therapies may result in CVD (Cardio-Oncology Syndrome Type II). There are many examples shown here in which anti-neoplastic therapies may result in acute or chronic CVD [22]. Pharmacotherapies, such as anthracyclines and HER2 receptor antagonists may result in myocardial dysfunction and heart failure. Immunotherapy can also induce cardiotoxicity. Radiation therapy may also result in the development of atherosclerosis, as well as damage to the heart valves or pericardium. CV, cardiovascular; ECM, extracellular matrix; HER2, human epidermal growth factor receptor 2. Adapted with permission; from Brown [23], Creative Commons Attribution License [CC BY]