Table 2 Longitudinal Assessment of Cardiopulmonary Function in Lung Cancer Patients Undergoing Radiotherapy

Body Composition & Physical Activity

Baseline

Follow-up

P-value

Body mass index, kg/m²

30.2 [24.4–35.1]

30.2 [23.4–35.2]

0.878

Physical Activity, MET/Min/week

1152 [122–1841]

759 [282–2804]

0.333

Health-related Quality of Life

FACT-G7

21.5 [18.8–25.0]

15.5 [11.5–20.0]

0.021

Lab Values

Hemoglobin, g/dL

12.7 [11.4–14.3]

12.6 [11.5–13.4]

0.102

hsCRP, mg/L

4.4 [1.4–5.8]

6.1 [3.7–20.7]

0.047

NT-proBNP, pg/mL

65 [49–125]

121 [88–191]

0.110

Pulmonary Function

FVC, %

84 [62–98]

84 [66–98]

0.959

FEV-1, %

75 [60–102]

79 [65–102]

0.575

FEV-1/FVC ratio

0.71 [0.64–0.85]

0.75 [0.70–0.83]

0.553

DLCO-corrected, %

62 [51–80]

60 [59–67]

0.779

Cardiopulmonary Exercise Test Variables

VO_2peak, L·min^− 1

1.245 [0.882–1.605]

1.095 [0.810–1.448]

0.047

VO_2peak, %-predicted

70 [62–86]

62 [56–76]

0.005

VO_2peak, mL·kg^− 1·min^− 1

13.8 [11.9–20.3]

13.5 [10.6–18.0]

0.047

VE/VCO₂ slope

31.0 [27.5–35.1]

32.7 [29.1–38.9]

0.139

OUES

1.63 [1.27–1.88]

1.57 [1.12–1.75]

0.032

Peak RER

1.11 [1.04–1.14]

1.12 [1.04–1.20]

0.241

Breathing reserve, %

61 [51–85]

65 [49–73]

0.515

Exercise time, sec

418 [355–707]

405 [331–643]

0.169

Resting heart rate, bpm

82 [63–84]

83 [70–92]

0.838

Peak heart rate, bpm

127 [119–148]

124 [118–134]

0.241

Resting systolic blood pressure, mmHg

139 [126–149]

122 [111–133]

0.109

Resting diastolic blood pressure, mmHg

81 [76–83]

78 [70–83]

0.539

Peak systolic blood pressure, mmHg

176 [152–198]

163 [138–191]

0.114

Peak diastolic blood pressure, mmHg

78 [74–86]

71 [70–76]

0.008

Rest Echo Parameters

Left-ventricular ejection fraction, %

62 [56–65]

66 [57–68]

0.475

Left-atrial volume index, mL/m²

26.9 [18.6–33.3]

24.3 [18.7–27.2]

0.646

E, cm/sec

71 [62–86]

72 [53–84]

0.285

A, cm/sec

81 [68–97]

86 [73–101]

0.093

E/A ratio

0.83 [0.69–1.11]

0.78 [0.66–0.96]

0.114

Septal e’, cm/sec

6.5 [5.5–8.2]

8.7 [7.7–11.1]

0.028

Lateral e’, cm/sec

9.8 [7.5–11.4]

11.2 [7.5–11.6]

0.646

Average e’, cm/sec

8.4 [6.5-9.0]

9.5 [7.5–10.7]

0.203

E/e’

7.9 [7.3–12.8]

7.5 [6.6–9.9]

0.169

Stress Echo Parameters

E, cm/sec

105 [87–127]

104 [74–116]

0.508

Septal e’, cm/sec

11.0 [9.5–13.3]

10.4 [8.6–12.3]

0.173

Lateral e’, cm/sec

13.1 [11.9–17.0]

11.8 [8.6–15.1]

0.139

Average e’, cm/sec

12.9 [11.0-13.7]

11.3 [8.5–13.4]

0.126

Δstress e’, cm/sec

4.5 [3.4–5.2]

1.3 [0.3–4.5]

0.022

E/e’

8.3 [5.5–10.7]

8.4 [7.1–11.3]

0.386

DFRI (e’ x Δstress e’)

34.9 [22.7–41.6]

12.8 [3.1–35.9]

0.037