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Table 2 Temporal Trends of biomarkers evaluated at two timepoints (baseline before chimeric antigen receptor-T cell infusion and 7 days after administration)

From: Inflammation and acute cardiotoxicity in adult hematological patients treated with CAR-T cells: results from a pilot proof-of-concept study

 

Baseline

7 days

p-value

 

Cardiac Biomarkers

   

hs-Troponin T, ng/mL [median (IQR)]

5.0 (4.0–6.0)

20.0 (7.0-94.5)

< 0,001

NT-proBNP, pg/mL [median (IQR)]

30.5 (15.5–124.0)

245.0 (152.0–363.0)

< 0,001

sST2, ng/mL [median (IQR)]

27.0 (21.5–42.8)

54.0 (24.5–140.0)

0.032

  1. hs = high sensitivity; NT-proBNP = N-terminal prohormone of brain natriuretic peptide; sST2 = soluble ST2