Fig. 1

a Relative LVEF change from baseline in LL3. Although there was no global tendency to decline, there were 3 LVEF measurements in LL3 that were reduced from baseline, and there were no increases beyond the 700-day mark; these represent 3 distinct patients whose LVEF reductions were not clinically significant (<10 % change from baseline) and were >50 % (the lowest LVEF was 61 %). b Relative LVEF change from baseline in LL1. Although there was no global tendency to decline beyond the 700-day mark, 7 LVEF measurements were reduced or at neutral; these 7 LVEF measurements were from 2 patients, and 1 patient had 3 measurements beyond day 700 (76.1 % on day 726, 76.9 % on day 810, and 74.4 % on day 894) that were close to his baseline LVEF of 76.80 %. Another patient had 4 LVEF measurements beyond day 700 (76.3 % on day 735, 65.3 % on day 819, 56.5 % on day 903, and 55.0 % on day 945); disease progression was diagnosed around the time of the final LVEF measurement. Abbreviations: LVEF, left ventricular ejection fraction; LL3, LUX-Lung 3; LL1, LUX-Lung 1