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Table 1 Different definitions of hypertension

From: Hypertension in cancer patients treated with anti-angiogenic based regimens

Definition of hypertensiona
Classification systems CTCAE 3.0 (2006)
(30)
CTCAE 4.03 (2010)
(26)
JNC-7 (2003)
(28)b
ESH/ESC (2013)
(27)
  Systolic Diastolic Systolic Diastolic Systolic Diastolic
Grade 1 Asymptomatic Transient (<24 h) Increase >20 (diastolic) > 150/100 if previously normal 120–139 80–89 140–159 90–99 140–159 90–99
Grade 2 Recurrent/persistent (≥24 h) symptomatic increase >20 (diastolic) > 150/100 if previously normal 140–159 90–99 ≥160 ≥100 160–179 100–109
Grade 3 Requiring >1 drug Requiring more intensive therapy than previously ≥160 ≥100 ND ND ≥180 ≥110
Grade 4 Life-threatening consequences Life-threatening consequences ND ND ND ND ND
Grade 5 ND Death ND ND ND ND ND
  1. Abbreviations: CTCAE common terminology criteria for adverse events, JNC joint national committee, ESH European society of hypertension, ESC European society of cardiology, ND not defined
  2. a All numeric blood pressure values are in mm Hg
  3. b The current JNC-8 report (2013) [115] does not classify grades of hypertension
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