Hypertension in cancer patients treated with anti-angiogenic based regimens

Cardio-Oncology

Table 1 Different definitions of hypertension

Definition of hypertension^a
Classification systems	CTCAE 3.0 (2006) (30)	CTCAE 4.03 (2010) (26)		JNC-7 (2003) (28)^b		ESH/ESC (2013) (27)
		Systolic	Diastolic	Systolic	Diastolic	Systolic	Diastolic
Grade 1	Asymptomatic Transient (<24 h) Increase >20 (diastolic) > 150/100 if previously normal	120–139	80–89	140–159	90–99	140–159	90–99
Grade 2	Recurrent/persistent (≥24 h) symptomatic increase >20 (diastolic) > 150/100 if previously normal	140–159	90–99	≥160	≥100	160–179	100–109
Grade 3	Requiring >1 drug Requiring more intensive therapy than previously	≥160	≥100	ND	ND	≥180	≥110
Grade 4	Life-threatening consequences	Life-threatening consequences	ND	ND	ND	ND	ND
Grade 5	ND	Death	ND	ND	ND	ND	ND

Abbreviations: CTCAE common terminology criteria for adverse events, JNC joint national committee, ESH European society of hypertension, ESC European society of cardiology, ND not defined
^a All numeric blood pressure values are in mm Hg
^b The current JNC-8 report (2013) [115] does not classify grades of hypertension

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