Fig. 4From: Targeting endothelial cell metabolism for cardio-protection from the toxicity of antitumor agentsMolecular mechanisms of zofenoprilat-induced protective effects on vascular ECs. Zofenoprilat induces a constant H2S production through CSE upregulation in vascular endothelium. On its turn H2S maintains ECs survival and stimulates the angiogenic process through a sequential pathway involving KATP channel/Akt/eNOS/ERK1/2 pathway (for details see [104])Back to article page