From: The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity
Sex | Treatment | Myocyte vacuolization; loss of myofibrils score | Coagulation necrosis; coagulative myocytolysis score | Interstitial cell proliferation; inflammation score | Cumulative heart score |
---|---|---|---|---|---|
Male | Saline | 1 (0–1) | 0 (0–1) | 0.5 (0–2) | 2 (0–3) |
 | DOX | 2 (2–3)* | 1 (0–2)* | 2 (1–3)* | 5 (4–7)* |
Female | Saline | 0 (0–1) | 0 (0–1) | 0.5 (0–1) | 1 (0–3) |
 | DOX | 2 (2–3)* | 1 (0–1) | 2 (1–2) | 5 (4–5)* |