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Table 1 Heart pathology scores in WKY rats based on evaluation of hematoxylin and eosin (HE) stained sections

From: The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity

Sex

Treatment

Myocyte vacuolization; loss of myofibrils score

Coagulation necrosis; coagulative myocytolysis score

Interstitial cell proliferation; inflammation score

Cumulative heart score

Male

Saline

1 (0–1)

0 (0–1)

0.5 (0–2)

2 (0–3)

 

DOX

2 (2–3)*

1 (0–2)*

2 (1–3)*

5 (4–7)*

Female

Saline

0 (0–1)

0 (0–1)

0.5 (0–1)

1 (0–3)

 

DOX

2 (2–3)*

1 (0–1)

2 (1–2)

5 (4–5)*

  1. Data are presented as the median and 95 % confidence interval of the median
  2. *p < 0.05 significantly different from Saline group of the same sex