Assessment of pazopanib-related hypertension, cardiac dysfunction and identification of clinical risk factors for their development

Table 2 Comparison of baseline characteristics in treatment-naïve metastatic renal cell carcinoma patients treated with pazopanib by occurrence of pazopanib-induced hypertension

Patient Characteristics	Total Cohort (N = 35)	Pazopanib-induced HTN (N = 20)	No Pazopanib-induced HTN (N = 15)	P-value
Male Gender	20 (57)	12 (60)	8 (53)	0.697
Age, years	61.9 ± 9.1	62.8 ± 10.4	60.7 ± 7.2	0.479
Pazopanib Therapy
Initial dose 800 mg QD	32 (91)	18 (90)	14 (93)	1
Initial dose 400 mg QD	3 (9)	2 (10)	1 (7)	1
Dose reduction	6 (17)	6 (30)	0 (0)	0.027
Tumor Histology
Clear cell	28 (80)	17 (85)	11 (73)	0.693
Papillary	4 (11)	2 (10)	2 (13)	0.712
Poorly differentiated	3 (9)	1 (5)	2 (13)	0.849
ECOG PS
0	8 (23)	7 (35)	1 (7)	0.101
1	19 (54)	10 (50)	9 (60)	0.734
≥2	8 (23)	3 (15)	5 (33)	0.246
Nephrectomy	22 (63)	12 (60)	10 (67)	0.687
Heart Failure	2 (6)	1 (5)	1 (7)	1
LV Dysfunction	7 (20)	2 (10)	5 (33)	0.112
Diabetes Mellitus	15 (43)	9 (45)	6 (40)	0.775
Hypertension	21 (60)	14 (70)	7 (47)	0.173
Systolic BP, mm Hg	126.9 ± 10.8	130.5 ± 10.9	121.7 ± 8.2	0.010
Diastolic BP, mm Hg	72.3 ± 7.4	74.4 ± 8.5	69.7 ± 4.4	0.045
Dyslipidemia	17 (49)	10 (50)	7 (47)	0.851
GFR < 60 mL/min/1.73 m²	20 (57)	11 (55)	9 (60)	0.767
CAD/PAD	5 (14)	2 (10)	3 (20)	0.631
CVA/TIA	3 (9)	3 (15)	0 (0)	0.244
Thromboembolism	7 (20)	3 (15)	4 (27)	0.430
Smoker	21 (60)	14 (70)	7 (47)	0.297
BMI, kg/m²	29.4 ± 8.7	28.8 ± 6.8	30.2 ± 11.0	0.680
ACEIs/ARBs	14 (40)	11 (55)	3 (20)	0.046
Beta Blockers	11 (31)	5 (25)	6 (40)	0.467
Diuretics	7 (20)	5 (25)	2 (13)	0.672
CCBs	9 (26)	7 (35)	2 (13)	0.244
Statin	13 (37)	8 (40)	5 (33)	0.737
Deceased	15 (43)	9 (45)	6 (40)	0.767
Follow-up time, months	10.0 [3.1-19.4]	11.7 [4.2-20.9]	6.9 [2.1-17.7]	0.257

HTN hypertension, QD once daily, ECOG Eastern Cooperative Oncology Group performance status, LV left ventricular, BP blood pressure, GFR glomerular filtration rate, CAD/PAD coronary artery disease/peripheral arterial disease, CVA/TIA cerebrovascular accident/transient ischemic attack, BMI body mass index, ACEI angiotensin converting enzyme inhibitor, ARB angiotensin receptor blocker, CCBs calcium channel blocker. Data presented as a number with percent (%), mean ± standard deviation, or median [1st quartile-3rd quartile]

ISSN: 2057-3804