Fig. 3

Rhythm tracings from 2 week continuous rhythm monitoring with a Zio patch (iRhythm, San Francisco, CA). Panel (a): Baseline asymptomatic recording demonstrating sinus rhythm with 1 ventricular ectopic beat. Normal ST segments are seen. Panel (b): Asymptomatic recording during sinus tachycardia at the highest heart rate documented during entire recording. Motion artifact is noted but overall no abnormal ST-T segments noted. Panel (c): Patient triggered event due to symptoms, demonstrating sinus tachycardia with approximately 0.5 mm ST-T segment depressions. The patient received carfilzomib earlier that day (during 6th cycle of treatment). Panel (d): Patient triggered event with symptoms 1 day after 6th cycle of treatment (day of Panel C) demonstrating sinus tachycardia with 0.5–1 mm ST-T segment depressions noted with symptoms