Fig. 4

Plasma profiling for specific determinants of inflammation and signaling. A number of inflammatory signaling pathways were profiled in plasma samples taken from age matched referent normal subjects and at the initial visit following AC treatment- identified as Visit 1. While robust signals for the soluble IL, TNF and VEGF receptors were detected in both referent normal and Visit 1 samples many soluble receptor analytes were similar between groups and summarized in Table A. On the other hand, specific soluble receptors/pathways were significantly different from referent control values and are shown in Figure 2-2B. These included the soluble receptors for IL-1, -2, and -4. A relative reduction in sRage and sVEGFR3 occurred in Visit 1 samples with an increase in Sgp130. (*p < 0.05 vs Visit 1 values). Normal: referent normal; MMP-2: Matrix metallopeptidase 2; MMP-7: Matrix metallopeptidase 7; MMP-9: Matrix metallopeptidase 9; IL-8: Interleukin 8; sVEGFR3: Fms-related tyrosine kinase 4; sgp130: Interleukin 6 signal transducer; sIL-1RII: Interleukin 1 receptor, type II; sIL-2Ra: Interleukin 2 receptor, alpha; sIL-4R: Interleukin 4 receptor