Table 2 LV Parameter trends (medians) by Cardiac Magnetic Resonance Imaging
Cumulative AC Dose (mg/m2) | High dose group (n = 3) | Low dose group (n = 10) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
30–60 | 125–175 | 200–250 | 275–325 | After Max | 1 Year After | p | 30–60 | 125–175 | After Max | 1 Year After | p | |
LV EF (%) | 66.8 | 61.2 | 58.7 | 57.6 | 55.8 | 55.3 | .005 | 62.6 | 60.8 | 60.4 | 57.9 | .11 |
LV EF z score | 0.57 | −0.62 | −1.1 | −1.4 | −1.7 | −1.9 | .005 | −0.3 | −0.6 | −0.8 | −1.3 | .11 |
LV EVDI (ml/m2) | 96.6 | 85.3 | 100.6 | 97.1 | 74.8 | 94.1 | .22 | 75.6 | 78.3 | 73.9 | 78.3 | .56 |
LV ESVI (ml/m2) | 23.5 | 33.2 | 40.3 | 41.1 | 31.8 | 41.5 | .30 | 29.3 | 30.7 | 29.9 | 33.0 | .58 |
LV SV (ml) | 132.3 | 88.5 | 87 | 85.6 | 77.5 | 99.2 | .35 | 73.4 | 67.5 | 73.9 | 67.6 | .93 |
LV Mass (g/m2) | 133 | 107.1 | 135 | 128 | 122 | 135.8 | .62 | 88.9 | 79.0 | 83 | 87.0 | .87 |
LV Mass z score | 0.4 | 0.7 | 0.2 | 0.5 | 0.3 | 0.6 | .42 | 0.6 | 0 | −0.2 | −0.2 | .03 |
LV Mass Volume (g/ml) | 0.7 | 0.8 | 0.8 | 0.8 | 0.9 | 0.8 | .26 | 0.8 | 0.8 | 0.7 | 0.7 | .19 |
LV Mass Volume z score | −1.0 | 0.5 | −0.3 | −0.5 | 0.9 | −0.4 | .54 | 0.5 | 0.7 | 0.3 | 0.2 | .28 |
ESFS (g/cm2) | 99 | 89.5 | 115 | 115 | 114 | 122 | .02 | 109 | 107.5 | 99 | 104 | .97 |
ESFS z score | 2.2 | 1.4 | 3.67 | 3.63 | 3.45 | 4.18 | .02 | 3.3 | 3.1 | 2.3 | 2.8 | .83 |
εcc (%) | −22.5 | −20.3 | −19.1 | −18.1 | −16.3 | −18.9 | .02 | −21.1 | −19.0 | −19.3 | − 19.9 | .45 |
ειι (%) | − 19.1 | −19.3 | − 16.2 | −15.8 | − 14.7 | −17.4 | .02 | −18.0 | − 16.0 | −15.5 | − 16.4 | .56 |