|
Cumulative AC Dose (mg/m2)
|
High dose group (n = 3)
|
Low dose group (n = 10)
|
|---|
|
30–60
|
125–175
|
200–250
|
275–325
|
After Max
|
1 Year After
|
p
|
30–60
|
125–175
|
After Max
|
1 Year After
|
p
|
|---|
|
LV EF (%)
|
66.8
|
61.2
|
58.7
|
57.6
|
55.8
|
55.3
|
.005
|
62.6
|
60.8
|
60.4
|
57.9
|
.11
|
|
LV EF z score
|
0.57
|
−0.62
|
−1.1
|
−1.4
|
−1.7
|
−1.9
|
.005
|
−0.3
|
−0.6
|
−0.8
|
−1.3
|
.11
|
|
LV EVDI (ml/m2)
|
96.6
|
85.3
|
100.6
|
97.1
|
74.8
|
94.1
|
.22
|
75.6
|
78.3
|
73.9
|
78.3
|
.56
|
|
LV ESVI (ml/m2)
|
23.5
|
33.2
|
40.3
|
41.1
|
31.8
|
41.5
|
.30
|
29.3
|
30.7
|
29.9
|
33.0
|
.58
|
|
LV SV (ml)
|
132.3
|
88.5
|
87
|
85.6
|
77.5
|
99.2
|
.35
|
73.4
|
67.5
|
73.9
|
67.6
|
.93
|
|
LV Mass (g/m2)
|
133
|
107.1
|
135
|
128
|
122
|
135.8
|
.62
|
88.9
|
79.0
|
83
|
87.0
|
.87
|
|
LV Mass z score
|
0.4
|
0.7
|
0.2
|
0.5
|
0.3
|
0.6
|
.42
|
0.6
|
0
|
−0.2
|
−0.2
|
.03
|
|
LV Mass Volume (g/ml)
|
0.7
|
0.8
|
0.8
|
0.8
|
0.9
|
0.8
|
.26
|
0.8
|
0.8
|
0.7
|
0.7
|
.19
|
|
LV Mass Volume z score
|
−1.0
|
0.5
|
−0.3
|
−0.5
|
0.9
|
−0.4
|
.54
|
0.5
|
0.7
|
0.3
|
0.2
|
.28
|
|
ESFS (g/cm2)
|
99
|
89.5
|
115
|
115
|
114
|
122
|
.02
|
109
|
107.5
|
99
|
104
|
.97
|
|
ESFS z score
|
2.2
|
1.4
|
3.67
|
3.63
|
3.45
|
4.18
|
.02
|
3.3
|
3.1
|
2.3
|
2.8
|
.83
|
|
εcc (%)
|
−22.5
|
−20.3
|
−19.1
|
−18.1
|
−16.3
|
−18.9
|
.02
|
−21.1
|
−19.0
|
−19.3
|
− 19.9
|
.45
|
|
ειι (%)
|
− 19.1
|
−19.3
|
− 16.2
|
−15.8
|
− 14.7
|
−17.4
|
.02
|
−18.0
|
− 16.0
|
−15.5
|
− 16.4
|
.56
|
- LV left ventricular, CMR cardiac magnetic resonance imaging, n number of subjects, AC anthracycline, EF ejection fraction, EDVI end diastolic volume index, ESVI end systolic volume index, SV stroke volume, ESFS end systolic fiber stress; εcc peak global circumferential strain magnitude; ειι: Peak global longitudinal strain magnitude. All patients in the low dose group had diagnosis of leukemia or lymphoma with Anthracycline cumulative doses of 175.2 ± 21.4 compared to 447.3 ± 4.6 (p < .0001) in the high dose group (solid tumor diagnosis)
- Bold numbers indicate statistically significant cardiac magnetic resonance imaging parameters
