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Table 1 Demographic, clinical, and vascular parameters

From: Resting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers

  Survivors (n = 96) Controls (n = 60) p
Demographic parameters
 Age (years) 25.0 ± 5.9 23.6 ± 5.8 0.16
 Sex (M/F) 54/42 30/30 0.45
 Weight (kg) 59.1 ± 10.8 59.2 ± 11.0 0.97
 Height (cm) 166.1 ± 8.7 165.9 ± 8.6 0.85
 Body mass index (kg/m2) 21.4 ± 3.2 21.4 ± 2.6 0.99
Clinical parameters in survivors
 Age at diagnosis (years) 8.0 ± 4.8
 Duration since completion of therapy (years) 15.4 ± 5.9
 Cumulative anthracycline dose (mg/m2) 258 ± 110 (range, 75–675)  
Diagnosis
 Acute lymphoblastic leukaemia 50   
 Non-Hodgkin lymphoma 15   
 Acute myeloid leukaemia 10   
 Osteosarcoma 4   
 Hodgkin lymphoma 5   
 Wilm’s tumour 6   
 Ewing Sarcoma 2   
 Clear cell sarcoma of kidney 1   
 Ganglioneuroblastoma 1   
 Neuroblastoma 1   
 Peripheral primitive neuroectodermal tumour 1   
Need for cardiac irradiation 5   
Relapse 9   
Cardiac medication 0   
Vascular parameters
Carotid arterial indices
  IMT (mm) 0.44 ± 0.03 0.41 ± 0.02 < 0.001
  Stiffness index 4.05 ± 0.02 3.85 ± 0.61 < 0.001
Radial pulse waveform indices
  Pulse pressure (mmHg) 42 ± 8 43 ± 9 0.34
  cSBP (mmHg) 111 ± 16 105 ± 16 0.037
  rAI (%) 64 ± 15 57 ± 13 0.004
  rAI at 75 beats/min (%) 64 ± 14 58 ± 12 0.009
  1. cSBP central systolic blood pressure, IMT intima-media thickness, rAI radial augmentation index