|
Demographic parameters
|
|
Age (years)
|
25.0 ± 5.9
|
23.6 ± 5.8
|
0.16
|
|
Sex (M/F)
|
54/42
|
30/30
|
0.45
|
|
Weight (kg)
|
59.1 ± 10.8
|
59.2 ± 11.0
|
0.97
|
|
Height (cm)
|
166.1 ± 8.7
|
165.9 ± 8.6
|
0.85
|
|
Body mass index (kg/m2)
|
21.4 ± 3.2
|
21.4 ± 2.6
|
0.99
|
|
Clinical parameters in survivors
|
|
Age at diagnosis (years)
|
8.0 ± 4.8
|
|
Duration since completion of therapy (years)
|
15.4 ± 5.9
|
|
Cumulative anthracycline dose (mg/m2)
|
258 ± 110 (range, 75–675)
| |
|
Diagnosis
|
|
Acute lymphoblastic leukaemia
|
50
| | |
|
Non-Hodgkin lymphoma
|
15
| | |
|
Acute myeloid leukaemia
|
10
| | |
|
Osteosarcoma
|
4
| | |
|
Hodgkin lymphoma
|
5
| | |
|
Wilm’s tumour
|
6
| | |
|
Ewing Sarcoma
|
2
| | |
|
Clear cell sarcoma of kidney
|
1
| | |
|
Ganglioneuroblastoma
|
1
| | |
|
Neuroblastoma
|
1
| | |
|
Peripheral primitive neuroectodermal tumour
|
1
| | |
|
Need for cardiac irradiation
|
5
| | |
|
Relapse
|
9
| | |
|
Cardiac medication
|
0
| | |
|
Vascular parameters
|
|
Carotid arterial indices
|
|
IMT (mm)
|
0.44 ± 0.03
|
0.41 ± 0.02
|
< 0.001
|
|
Stiffness index
|
4.05 ± 0.02
|
3.85 ± 0.61
|
< 0.001
|
|
Radial pulse waveform indices
|
|
Pulse pressure (mmHg)
|
42 ± 8
|
43 ± 9
|
0.34
|
|
cSBP (mmHg)
|
111 ± 16
|
105 ± 16
|
0.037
|
|
rAI (%)
|
64 ± 15
|
57 ± 13
|
0.004
|
|
rAI at 75 beats/min (%)
|
64 ± 14
|
58 ± 12
|
0.009
|
