Fig. 5
From: Systemic and cardiac susceptibility of immune compromised mice to doxorubicin
Liver morphology and histology of saline and doxorubicin injected NOD/Scid mice. a Gross morphology of the liver from saline and doxorubicin injected mice. The liver from the doxorubicin-injected mouse was the worst case observed, however varying degrees of liver atrophy were observed in all animals from all three studies. b a, a’, b and b’: H & E stain of liver showing hemosiderin deposits (b’, brown staining/white arrows) in the doxorubicin exposed liver. c, c’, d and d’: Iron staining confirms deposition of hemosiderin (d and d’, blue stain/white arrows) throughout the liver in doxorubicin treated mice. e, e’, f and f’: Masson trichrome staining reveals a thickened fibrous capsule in doxorubicin treated mice (f’, white brackets). g, g’, h and h’: Reticulin staining confirms a thick fibrous cap in doxorubicin treated mice (h’, white bracket). i, i’, j and j’: PAS and PAS-D staining to show the presence or absence of glycogen stores. Saline treated mice show red staining in their livers (i, white arrows), which disappears with dispase treatment (i’, PAS-D). Doxorubicin treated mice do not show staining with PAS, suggesting depleted hepatic glycogen stores (j and j’). Representative images shown from study III mice