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Table 1 Design of all three studies

From: Systemic and cardiac susceptibility of immune compromised mice to doxorubicin

Study Weekly Doxorubicin Dose Cumulative Doxorubicin Dose # Saline Mice # Doxorubicin Mice
I 4 mg/kg 8 mg/kg 14 (7♀, 7♂) 14 (7♀, 7♂)
II Dose escalation: 0.5 mg/kg with weekly increases by 0.5 mg/kg 5 mg/kg N/A 5 (3♂, 2♀)
III 0.5 mg/kg 3 mg/kg 4 (2♀, 2♂) 4 (2♀, 2♂)