Table 2 Case reports of cancer drugs reported to cause Takotsubo Cardiomyopathy with details of the case (cancer drug, type of cancer, patient demographics, presence or absence of chest pain, and results of cardiac testing)

[18]

F

No

Stage III colorectal cancer

Continuous 5- FU infusion [as part of FOLFOX]

First cycle

Yes

Sinus Tachycardia; STE in II,III,aVF, V4,V5,V6

Trop-I = 0.38 (N/A)

[19]

F

No

Rectal adenocarcinoma

5 FU + Levofolinate

Sixth cycle

Yes

STE in V1-V3

Trop-T = 0.82 (N/A)

[20]

F

No

Metastatic adenocarcinoma of the colon

FOLFOX (5 FU, Leucovorin, Oxaliplatin)

First cycle

No

Non specific lateral ST changes and poor R wave progression

Trop-T = 0.64 (< 0.03)

[21]

M

No

Squamous cell carcinoma of soft palate

Cisplatin + 5-FU

First cycle

No

Sinus tachycardia; LVH with repolarization changes

N/A

[17]

M

N/A

Metastatic adenocarcinoma of the colon

FOLFOX (5 FU, Leucovorin, Oxaliplatin)

First cycle

Yes

Lateral STE with reciprocal changes with intermittent LBBB

Trop-I = 4.07 (N/A)

[22]

M

No

Adenocarcinoma of the colon

FOLFOX (5 FU, Leucovorin, Oxaliplatin)

First cycle

Yes

Apicolateral STD and TWI

Trop = 0.5 (< 0.1)

[23]

M

N/A

Invasive adenocarcinoma of sigmoid colon

FOLFOX (5 FU, Leucovorin, Oxaliplatin)

First cycle

Yes

Upsloping STE and hyperacute T wave changes in septal, inferior, and lateral leads

Trop-I = 1.0 (< 0.04)

[24]

M

No

Gastric adenocarcinoma

DCF (Docetaxel, Cisplatin, 5-FU) followed by FOLFIRI (5-FU, Folinic acid, Irinotecan)

Seventh cycle

No

Sinus tachycardia; TWI in V4,V5

Trop-I = 2.87 (< 0.04)

[25]

M

No

Metastatic nasopharyngeal carcinoma

Cisplatin + 5-FU infusion

First cycle

No

Sinus tachycardia with no ST-T changes

N/A

[26]

F

No

Metastatic adenocarcinoma of the Colon

5 FU

Tenth cycle

Yes

STE in anterior and inferior leads

Trop-T = 1.06 (< 0.04)

[20]

F

No

Stage III colorectal cancer

5-FU + Folinic Acid switched to Capecitabine

5 cycles of 5-FU, First cycle of Capecitabine

Yes

TWI in anteroseptal, inferior, and lateral leads

Trop-T = 0.35 (N/A)

[27]

F

N/A

Metastatic invasive ductal breast carcinoma

Capecitabine

First cycle

Yes

Nonspecific ST-T wave changes, followed by new STE in the inferolateral leads; STD and TWI in leads V1 and V2

Trop-I = 0.19 (0–0.75)

[28]

M

No

Adenocarcinoma of the caecum

Capecitabine

First cycle

Yes

1–2 mm STE in V2–6; 1 mm STD in aVR, II and aVF

HS Trop = 89 (N/A)

[29]

M

No

Adenocarcinoma of the colon

Capecitabine

First cycle

No

STE in precordial leads

N/A

[30]

F

No

Inflammatory breast cancer

Capecitabine

First cycle

No

Sinus tachycardia; TWI in anterolateral leads

Trop-I = 0.34 (N/A)

[31]

M

N/A

Colon cancer

Bevacizumab

First cycle

No

Anterior and inferior STE

N/A

[31]

M

N/A

Non small cell lung cancer

Bevacizumab

Second cycle

No

Tachycardia; new inferior Q waves; diffuse STE

Trop = 2.5 (N/A)

[32]

F

No

Anaplastic thyroid cancer

Combretastatin + Cisplatin + Doxorubicin

First cycle

No

TWI in I, aVL, V2- V6

Trop-I = 0.85 (< 0.15)

F

No

Anaplastic thyroid cancer

Combretastatin + Cisplatin + Doxorubicin

First cycle

No

Deep symetric TWI in precordial leads

N/A

[33]

M

No

CLL

Rituximab + Methylprednisone

Thirteenth cycle

No

Sinus tachycardia; STE in I, II, V4–6

Trop = 0.14 (< 0.04)

[34]

F

No

Clear cell renal carcinoma

Sunitinib

N/A

Yes

STE

Trop-T = 1.2 (< 0.04)

[35]

F

No

Metastatic renal cell carcinoma

Axitinib

First cycle

Yes

Anterolateral STE

Trop-I = 6.95 (N/A)

[36]

F

No

Invasive ductal carcinoma of breast

Trastuzumab + Docetaxel + Carboplatin

Eleventh cycle

Yes

TWI in V1–2, I, aVL

Trop-T = 0.15 (< 0.02)

[37]

M

No

Non M3-AML

Cytarabine + Daunorubicin

First cycle (Day 6)

Yes

Sinus tachycardia; STE in I, aVL, V5, V6

Trop-I = 38.64 (< 0.1)

[38]

F

No

Metastatic melanoma

Ipilimumab

Fourth cycle

Yes

Sinus tachycardia; 1 mm STE in I, V2, V3

Trop-I = 0.98 (< 0.04)