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Table 3 Short and long-term outcomes post-TAVR

From: Clinical outcomes after transcatheter aortic valve replacement in cancer survivors treated with ionizing radiation

Outcomesa

All Subjects (n = 610)

Non- XRT Group (n = 535)

C-XRT Group (n = 75)

P value

Early Events

 ICU LOS (hrs)

41.9 ± 43.1

41.50 ± 43.19

44.67 ± 43.00

0.55

 Hospital LOS (days)

5.2 ± 6.5

5.32 ± 6.84

4.52 ± 3.64

0.31

 In Hospital AMI

1 (0.16)

1 (0.19)

0 (0)

1.0

 In Hospital AF

49 (8.03)

13 (2.43)

36 (48.00)

< 0.0001

 In Hospital stroke

9 (1.48)

5 (0.93)

4 (5.33)

0.01

 In Hospital cardiac arrest

20 (3.28)

15 (2.80)

5 (6.67)

0.08

 In Hospital Mortality

17 (2.79)

12 (2.24)

5 (6.67)

0.04

 30-day Mortality

17 (2.79)

12 (2.24)

5 (6.67)

0.04

 Major bleed

63 (10.33)

52 (9.72)

11 (14.67)

0.22

Long-term Events

 AMI and/or urgent PCI

35 (5.74)

31 (5.79)

4 (5.33)

1.00

 Stroke/TIA

36 (5.90)

27 (5.05)

9 (12.00)

0.03

 HF admission

113 (18.52)

90 (16.82)

23 (30.67)

0.006

 PPM implants

64 (10.49)

49 (9.16)

15 (20.0)

0.007

 CV Mortality

50 (48.54)

36 (44.44)

14 (63.64)

0.14

 All-Cause Mortality

103 (16.89)

81 (15.14)

22 (29.33)

0.004

 MACE

185 (30.33)

144 (26.92)

41 (54.67)

< 0.0001

Quality of Life measures

 Home Disposition post TAVR

513 (84.10)

451 (84.30)

62 (82.67)

0.73

 KCCQ12 at 30 days

79.23 ± 17.11

79.27 ± 16.98

78.96 ± 18.20

0.88

 KCCQ12 at 1 year

83.02 ± 13.47

82.86 ± 13.55

84.29 ± 12.81

0.44

  1. C-XRT indicates mediastinal radiation therapy
  2. ICU intensive care unit, LOS length of stay, AF atrial Fibrillation, AMI acute myocardial infarction, PCI percutaneous coronary intervention, TIA transient ischemic attack, HF heart failure, PPM permanent pacemaker, CV cardiovascular, MACE major cardiovascular adverse event (CV death/MI/Stroke/HF), KCCQ12 Kansas City Cardiomyopathy Questionnaire
  3. aValues are expressed as number (percentage) or mean ± SD