Fig. 2
From: The hypertensive effect of sorafenib is abolished by sildenafil
Concentration response curves of sorafenib in endothelium intact rat aortic rings, in the presence of solvent (Solv, full circles) or different inhibitors (full squares): U73122 (a), L-NAME (b), ODQ (c; full diamonds, endothelium denuded), manoalide (d), indomethacin (INDO, e) and rofecoxib (ROFE, f). Each point is the mean ± SEM of 5–15 rats. * P < 0.001 vs 10− 10 M; †††P < 0.001 vs Solvent. ANOVA for repeated measures