Table 1 Inhibitors of the different pathways implicated in vasorelaxation
From: The hypertensive effect of sorafenib is abolished by sildenafil
| Drugs | Selectivity | Concentration (M) | References |
|---|---|---|---|
| U73122 | Phospholipase C | 10−5 | [35] |
| Manoalide | Phospholipase A2 | 3.10−7 | [36] |
| L-NAME | Nitric oxide (NO) synthase | 3.10− 5 | [37] |
| Indomethacin (INDO) | Cyclo-oxygenase (COX) | 3.10− 5 | [38, 39] |
| Rofecoxib | Prostacyclin (PGI2) synthase | 3.10−7 | [38,39,40] |
| ODQ | Soluble guanylyl cyclase (sGC) | 10−5 | [41,42,43] |
| Ouabain | Na/K-ATPase | 10−4 | [44] |