Table 1 Inhibitors of the different pathways implicated in vasorelaxation
From: The hypertensive effect of sorafenib is abolished by sildenafil
Drugs | Selectivity | Concentration (M) | References |
|---|---|---|---|
U73122 | Phospholipase C | 10−5 | [35] |
Manoalide | Phospholipase A2 | 3.10−7 | [36] |
L-NAME | Nitric oxide (NO) synthase | 3.10− 5 | [37] |
Indomethacin (INDO) | Cyclo-oxygenase (COX) | 3.10− 5 | |
Rofecoxib | Prostacyclin (PGI2) synthase | 3.10−7 | |
ODQ | Soluble guanylyl cyclase (sGC) | 10−5 | |
Ouabain | Na/K-ATPase | 10−4 | [44] |