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Table 1 List of Selected Studies with Their Demographics, Duration, Sample Size, Mean Age, Radiation Doses, and Cardiovascular Outcomes

From: Gender disparity in cardiovascular mortality following radiation therapy for Hodgkin’s lymphoma: a systematic review

Trial Information

Country

Duration

Sample (%)

Mean Age (Years)

Median Radiation Dose (Gy)

Outcome

Female

Male

Boivin 1982, [19]

Retrospective study

USA

33.0 years

44.2

55.8

< 44

> 30

CV mortality

Galper 2011, [2]

Retrospective study

USA

14.7 years

53.6

46.4

47

> 36

CAD (MI, CABG, PTCA), arrhythmias (AICD), valvular disease, pericardial disease

Giancolo 2010, [20]

Prospective study

Italy

5.0 months

46.4

53.6

47.8 +/− 17.4

41.2+/−15.6

CIMT

Hahn 2017, [21]

Retrospective study

Canada

One time analysis

39.2

60.8

34.2

25

Ischemic CVD

Heidenreich 2007, [22]

Prospective study

USA

One time analysis

45.4

54.6

42

> 35

Asymptomatic CAD stress testing, followed by coronary angiography if positive stress test

Hoppe 1997, [23]

Prospective study

USA

35.0 years

41.0

59.0

NA

> 30

Cardiac heart disease (pericarditis, coronary artery disease, functional valvular/conduction defects)

Hull 2003, [10]

Retrospective study

USA

11.2 years

39.0

61.0

25

33

CAD (MI, CABG, PCI, > 75% stenosis)

Schellong 2010, [24]

Prospective study

Germany, Austria

29.4 years

41.7

58.3

27.9

> 30

Cardiac heart disease (pericarditis, coronary artery disease, functional valvular/conduction defects)

Swerdlow 2007, [25]

Prospective study

UK

25.0 years

38.1

61.9

34

> 30

CVD mortality

Tsai 2011, [26]

Prospective study

Norway

20.0–24.0 years

77.5

22.5

51 +/− 9

41

LV wall motion and EF, and CAD

  1. Abbreviations: UK United Kingdom, CVD Cardiovascular Disease, CAD Coronary Artery Disease, MI Myocardial Infarction, CABG Coronary Artery Bypass Graft, PTCA Percutaneous Coronary Balloon Angiogram, AICD Automatic Intrac-cardiac Defibrillator, CIMT Common Carotid Intima-Media Thickness, PCI Percutaneous Coronary Intervention, LV Left Ventricle, EF Ejection Fraction