Atlas-based measures of left ventricular shape may improve characterization of adverse remodeling in anthracycline-exposed childhood cancer survivors: a cross-sectional imaging study

Table 2 Comparison of Left Ventricular Size and Shape Between the Survivor Cohort and the Reference Population

	Reference Population (N = 1991)^a	Survivor Cohort (N = 20)^a	P^†
Conventional MRI Parameters
LVEF, %	62.9 (7.3)	56.6 (6.2)	0.006
LVEDV, ml	125.4 (31.2)	113.9 (31.1)	< 0.001
Indexed LVEDV, ml/m^2.7	31.8 (6.5)	28.3 (7.1)	< 0.001
LV Mass, gr	126.2 (36.0)	96.5 (26.4)	< 0.001
Indexed LV Mass, gr/m^2.7	31.8 (7.4)	23.7 (5.0)	< 0.001
Mass/Volume	1.02 (0.22)	0.86 (0.20)	0.062
Atlas-Derived Parameters
Shape Mode 1	0.0 (1.0)	−0.5 (0.8)	< 0.001
Shape Mode 2	0.0 (1.0)	−1.8 (1.1)	< 0.001
Shape Mode 3	0.0 (1.0)	0.4 (1.4)	0.092
Shape Mode 4	0.0 (1.0)	0.0 (1.2)	0.412
Shape Mode 5	0.0 (1.0)	0.4 (1.1)	0.061

LV Left Ventricle, LVEDV Left Ventricular End-Diastolic Volume, LVEF Left Ventricular Ejection Fraction, MRI Magnetic Resonance Imaging
^aFor each group, the raw mean and standard deviation are shown
†Linear regression determined the association of each MRI parameter with cohort, adjusting for age, ethnicity, and hypertension, and P-values were derived from Wald tests

ISSN: 2057-3804