Atlas-based measures of left ventricular shape may improve characterization of adverse remodeling in anthracycline-exposed childhood cancer survivors: a cross-sectional imaging study

Table 3 Comparison of Left Ventricular Size and Shape in the Survivor Cohort by Anthracycline Dose

	Low-Dose (N = 10)^a	High-Dose (N = 10)^a	P^†
Conventional MRI Parameters
LVEF, %	57.2 (7.3)	55.9 (5.1)	0.663
LVEDV, ml	115.3 (17.8)	112.4 (41.4)	0.840
Indexed LVEDV, ml/m^2.7	29.5 (6.2)	27.1 (8.0)	0.459
LV Mass, gr	101.5 (19.2)	91.4 (32.4)	0.405
Indexed LV Mass, gr/m^2.7	25.6 (3.7)	21.8 (5.7)	0.085
Mass/Volume	0.90 (0.21)	0.83 (0.18)	0.434
Atlas-Derived Parameters
Shape Mode 1	−0.3 (0.6)	−0.7 (1.0)	0.311
Shape Mode 2	−1.8 (1.0)	−1.7 (1.1)	0.785
Shape Mode 3	0.7 (1.7)	0.2 (1.1)	0.419
Shape Mode 4	0.6 (1.0)	−0.5 (1.3)	0.039
Shape Mode 5	0.4 (1.2)	0.3 (1.0)	0.870

LV Left Ventricle, LVEDV Left Ventricular End-Diastolic Volume, LVEF Left Ventricular Ejection Fraction, MRI Magnetic Resonance Imaging
^aFor each group, the mean and standard deviation are shown
†P-values are derived from two-sample T tests

ISSN: 2057-3804