Severe combined cardiac and neuromuscular toxicity from immune checkpoint blockade: an institutional case series

Cardio-Oncology

Table 2 Range of toxicities for each case

Case	Cardiovascular Toxicity	Neurologic/Ocular Toxicity	Myositis	Hepatitis	Respiratory Failure	Other
1	Myocarditis Complete Heart Block	Myasthenia Gravis	+	+	+	–
2	Myocarditis, Complete Heart Block, Pulmonary Embolism	Myasthenia Gravis	+	+	–	Gastritis
3	Myocarditis	Myasthenia Gravis	+	+	–	SIADH
4	Myocarditis	Stroke	–	–	–	–
5	Myocarditis	Myasthenia Gravis	+	+	+	–
6	Pericarditis	Myasthenia Gravis	+	+	+	–
7	Myocarditis	Myasthenia Gravis	+	+	+	Gastritis
8	Myocarditis, Complete Heart Block	Myasthenia Gravis	+	+	–	–

Each case had multiple overlapping toxicities after presenting with primarily a cardiac symptom. SIADH syndrome of inappropriate anti-diuretic hormone

ISSN: 2057-3804