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Table 2 Echocardiographic outcomes of patients with early- and late diagnosed ACD

From: Early- and late anthracycline-induced cardiac dysfunction: echocardiographic characterization and response to heart failure therapy

 

Overall (n = 92)

Early (n = 49)

Late (n = 43)

p-value

Left ventricle

 IVSd (mm)

9.7 (1.8)

9.8 (1.7)

9.6 (1.9)

0.543

 PWd (mm)

9.5 (1.6)

9.6 (1.6)

9.4 (1.7)

0.483

 LVIDd (mm)

49.7 (6.8)

50.0 (7.3)

49.3 (6.3)

0.630

 iLV mass (g/ m2)

89.9 (23.9)

91.3 (21.1)

88.4 (26.9)

0.572

 Increased iLV mass (n) a

15 / 91 (17)

8 (17)

7 (17)

0.319

 iEDV (mL/m2)

63.3 (15.5)

63.6 (14.8)

62.9 (16.4)

0.840

 Dilated (n) a

19 (21)

9 (18)

10 (23)

0.334

 iESV (mL/m2)

36.2 (11.2)

35.9 (9.6)

36.5 (13.0)

0.813

 Dilated (n) a

69 (75)

40 (82)

29 (67)

0.178

 LVEF (%)

43.3 (5.5)

43.6 (4.9)

43.0 (6.2)

0.576

 GLS (%)

−13.5 (3.3)

−13.2 (3.1)

−13.7 (3.5)

0.550

Right ventricle

 Basal RV dimension (mm)

32.8 (6.2)

32.6 (5.4)

33.0 (7.1)

0.756

RV function (n = 91)

 TAPSE (mm)

19.5 (4.6)

19.5 (4.3)

19.6 (4.9)

0.905

 S′ (cm/sec)

12.1 (2.8)

12.2 (2.7)

11.9 (2.9)

0.632

 Impaired (n) a

14 (15)

7 (15)

7 (16)

0.823

 Systolic RV pressure (mmHg)

21.4 (5.6)

21.0 (5.2)

21.9 (6.1)

0.617

Diastolic function (n = 89)

 LAVI (mL/m2)

28.6 (9.1)

29.1 (8.2)

28.0 (9.9)

0.598

 E (cm/sec)

55.0 (18.5)

54.7 (15.80

55.5 (21.4)

0.840

 A (cm/sec)

63.0 (17.0)

63.7 (17.3)

62.2 (16.9)

0.696

 E/A ratio

0.91 (0.39)

0.91 (0.40)

0.91 (0.39)

0.961

 E deceleration time (msec)

176 (51)

182 (60)

169 (37)

0.271

 E’ (cm/sec)

8.1 (2.9)

8.0 (3.0)

8.2 (2.8)

0.747

 E/E’

7.2 (2.6)

7.3 (2.5)

7.1 (2.7)

0.771

  1. Categorical variables are expressed as n (%) and continuous variables as mean (standard deviation) or median [interquartile range]. IVSd end-diastolic intraventricular septal dimension, PWd End-diastolic posterior wall dimension, LVEDD Left ventricular end-diastolic dimension, iLV Indexed left ventricular (mass), iEDV Indexed end-diastolic volume, iESV Indexed end-systolic volume, LVEF Left ventricular ejection fraction, GLS Global longitudinal strain, RV Right ventricle, TAPSE Tricuspid annular plain systolic excursion; S′ Doppler Tissue Imaging-derived S-wave, LAVI Left atrial volume index; a References values of echocardiographic measurements are provided in supplemental Table 1