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Table 2 Echocardiographic outcomes of patients with early- and late diagnosed ACD

From: Early- and late anthracycline-induced cardiac dysfunction: echocardiographic characterization and response to heart failure therapy

  Overall (n = 92) Early (n = 49) Late (n = 43) p-value
Left ventricle
 IVSd (mm) 9.7 (1.8) 9.8 (1.7) 9.6 (1.9) 0.543
 PWd (mm) 9.5 (1.6) 9.6 (1.6) 9.4 (1.7) 0.483
 LVIDd (mm) 49.7 (6.8) 50.0 (7.3) 49.3 (6.3) 0.630
 iLV mass (g/ m2) 89.9 (23.9) 91.3 (21.1) 88.4 (26.9) 0.572
 Increased iLV mass (n) a 15 / 91 (17) 8 (17) 7 (17) 0.319
 iEDV (mL/m2) 63.3 (15.5) 63.6 (14.8) 62.9 (16.4) 0.840
 Dilated (n) a 19 (21) 9 (18) 10 (23) 0.334
 iESV (mL/m2) 36.2 (11.2) 35.9 (9.6) 36.5 (13.0) 0.813
 Dilated (n) a 69 (75) 40 (82) 29 (67) 0.178
 LVEF (%) 43.3 (5.5) 43.6 (4.9) 43.0 (6.2) 0.576
 GLS (%) −13.5 (3.3) −13.2 (3.1) −13.7 (3.5) 0.550
Right ventricle
 Basal RV dimension (mm) 32.8 (6.2) 32.6 (5.4) 33.0 (7.1) 0.756
RV function (n = 91)
 TAPSE (mm) 19.5 (4.6) 19.5 (4.3) 19.6 (4.9) 0.905
 S′ (cm/sec) 12.1 (2.8) 12.2 (2.7) 11.9 (2.9) 0.632
 Impaired (n) a 14 (15) 7 (15) 7 (16) 0.823
 Systolic RV pressure (mmHg) 21.4 (5.6) 21.0 (5.2) 21.9 (6.1) 0.617
Diastolic function (n = 89)
 LAVI (mL/m2) 28.6 (9.1) 29.1 (8.2) 28.0 (9.9) 0.598
 E (cm/sec) 55.0 (18.5) 54.7 (15.80 55.5 (21.4) 0.840
 A (cm/sec) 63.0 (17.0) 63.7 (17.3) 62.2 (16.9) 0.696
 E/A ratio 0.91 (0.39) 0.91 (0.40) 0.91 (0.39) 0.961
 E deceleration time (msec) 176 (51) 182 (60) 169 (37) 0.271
 E’ (cm/sec) 8.1 (2.9) 8.0 (3.0) 8.2 (2.8) 0.747
 E/E’ 7.2 (2.6) 7.3 (2.5) 7.1 (2.7) 0.771
  1. Categorical variables are expressed as n (%) and continuous variables as mean (standard deviation) or median [interquartile range]. IVSd end-diastolic intraventricular septal dimension, PWd End-diastolic posterior wall dimension, LVEDD Left ventricular end-diastolic dimension, iLV Indexed left ventricular (mass), iEDV Indexed end-diastolic volume, iESV Indexed end-systolic volume, LVEF Left ventricular ejection fraction, GLS Global longitudinal strain, RV Right ventricle, TAPSE Tricuspid annular plain systolic excursion; S′ Doppler Tissue Imaging-derived S-wave, LAVI Left atrial volume index; a References values of echocardiographic measurements are provided in supplemental Table 1