Hospitalized cancer patients with acquired long QT syndrome-a matched case-control study

Cardio-Oncology

Table 1 Clinical characteristics in hospitalized malignant cancer patients with and without severe ALQTS

ECG and clinical aspects	ALQTS (n = 150)	Non-ALQTS (n = 293)	p value
Age (years)	62 ± 13	62 ± 13	0.331
Gender
Female	58%	58%	0.887
Male	42%	42%
Comorbidities
Hypertension	29.3%	16.4%	0.001
Heart Failure	6.7%	0.7%	< 0.001
Arrhythmia	6.7%	2.7%	0.047
Renal Insufficiency	5.3%	2.7%	0.165
Infection	21.3%	5.1%	< 0.001
Type 2 mellitus	16.0%	9.6%	0.046
Neurologic diseases	10.7%	3.4%	0.002
Anemia	12.0%	1.4%	< 0.001
ECG Data
Heart rate (bpm)	88 ± 17	72 ± 12	< 0.001
QTc (ms) φ	520 (20)	422 (18)	< 0.001
Laboratory Test
Hypokalemia	31.7%	5.2%	< 0.001
Hypocalcemia	22.7%	4.9%	< 0.001
Medications
QT-prolonging drugs	31.3%	6.8%	< 0.001
Chemotherapeutic drugs
Anti-microtubule agents	36%	28%	0.084
Platinum	34%	31.1%	0.530
Antimetabolites	33.3%	27.3%	0.187
Alkylating agents	29.1%	17.7%	0.215
Anthracyclines	28%	28.1%	0.151
Arsenic trioxide	2%	1.4%	0.612

Values are expressed as mean ± SD or median (interquartile range) unless otherwise indicated. φ Median (inter-quartile range) is shown. Abbreviations: ALQTS acquired long QT syndrome, ECG electrocardiograph

ISSN: 2057-3804