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Table 1 Baseline characteristic by cardiotoxicity (defined as drop EF>10% from baseline and EF< 50% at each time measurement)

From: Baseline global longitudinal strain predictive of anthracycline-induced cardiotoxicity

  Total
N = 188
Cardiotoxicity P-value
No
N = 165
Yes
N = 23
Age (years) 53.89 ± 14.40 52.92 ± 14.59 60.87 ± 10.89 0.013
Male 62 (32.98) 50 (30.3) 12 (52.17) 0.056
BMI (kg/m2) 28.40 ± 6.08 28.40 ± 6.20 28.44 ± 5.19 0.98
Race     0.40
 Asian 5 (2.66) 5 (3.03) 0 (0.00)  
 Black 24 (12.77) 21 (12.73) 3 (13.04)  
 Caucasian 99 (52.66) 84 (50.91) 15 (65.22)  
 Hispanic 50 (26.60) 47 (28.48) 3 (13.04)  
 Other 10 (5.32) 8 (4.85) 2 (8.70)  
Systolic 129.42 ± 17.68 128.22 ± 16.35 137.74 ± 23.86 0.015
Diastolic 70.97 ± 10.66 70.67 ± 10.62 73.09 ± 10.93 0.31
Heart Rate 76.38 ± 13.31 76.23 ± 13.28 77.53 ± 13.85 0.69
Family history of Heart Disease 19 (10.11) 15 (9.09) 4 (17.39) 0.26
Diabetes 35 (18.62) 29 (17.58) 6 (26.09) 0.39
Hypertension 80 (42.55) 64 (38.79) 16 (69.57) 0.007
Hyperlipidemia 52 (27.66) 44 (26.67) 8 (34.78) 0.46
Coronary Artery Disease 9 (4.79) 8 (4.85) 1 (4.35) 1.00
Hypothyroidism 21 (11.17) 20 (12.12) 1 (4.35) 0.48
Smoking 48 (25.53) 33 (20.00) 15 (65.22) < 0.001
Ejection Fraction 64.09 ± 3.94 64.43 ± 3.73 61.70 ± 4.60 0.002
Baseline GLS -19.13 ± 2.91 -19.36 ± 2.86 -17.51 ± 2.77 0.004
Cancer type     0.018
 Breast 80 (42.55) 76 (46.06) 4 (17.39)  
 Hematologic 99 (52.66) 81 (49.09) 18 (78.26)  
 Other 9 (4.79) 8 (4.85) 1 (4.35)  
Chemotherapy dose 168.70 ± 102.91 175.62 ± 102.49 118.02 ± 93.32 0.013
  1. Data were presented as mean ± SD for continuous variables and number (%) for categorical variables. Chi-square or Fisher’s exact test (categorical variables) and t-test or Mann-Whitney test (continuous variables) were used to compare patients between cardiotoxicity status
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