Table 1 Baseline characteristic by cardiotoxicity (defined as drop EF>10% from baseline and EF< 50% at each time measurement)
From: Baseline global longitudinal strain predictive of anthracycline-induced cardiotoxicity
Total N = 188 | Cardiotoxicity | P-value | ||
|---|---|---|---|---|
No N = 165 | Yes N = 23 | |||
Age (years) | 53.89 ± 14.40 | 52.92 ± 14.59 | 60.87 ± 10.89 | 0.013 |
Male | 62 (32.98) | 50 (30.3) | 12 (52.17) | 0.056 |
BMI (kg/m2) | 28.40 ± 6.08 | 28.40 ± 6.20 | 28.44 ± 5.19 | 0.98 |
Race | 0.40 | |||
Asian | 5 (2.66) | 5 (3.03) | 0 (0.00) | |
Black | 24 (12.77) | 21 (12.73) | 3 (13.04) | |
Caucasian | 99 (52.66) | 84 (50.91) | 15 (65.22) | |
Hispanic | 50 (26.60) | 47 (28.48) | 3 (13.04) | |
Other | 10 (5.32) | 8 (4.85) | 2 (8.70) | |
Systolic | 129.42 ± 17.68 | 128.22 ± 16.35 | 137.74 ± 23.86 | 0.015 |
Diastolic | 70.97 ± 10.66 | 70.67 ± 10.62 | 73.09 ± 10.93 | 0.31 |
Heart Rate | 76.38 ± 13.31 | 76.23 ± 13.28 | 77.53 ± 13.85 | 0.69 |
Family history of Heart Disease | 19 (10.11) | 15 (9.09) | 4 (17.39) | 0.26 |
Diabetes | 35 (18.62) | 29 (17.58) | 6 (26.09) | 0.39 |
Hypertension | 80 (42.55) | 64 (38.79) | 16 (69.57) | 0.007 |
Hyperlipidemia | 52 (27.66) | 44 (26.67) | 8 (34.78) | 0.46 |
Coronary Artery Disease | 9 (4.79) | 8 (4.85) | 1 (4.35) | 1.00 |
Hypothyroidism | 21 (11.17) | 20 (12.12) | 1 (4.35) | 0.48 |
Smoking | 48 (25.53) | 33 (20.00) | 15 (65.22) | < 0.001 |
Ejection Fraction | 64.09 ± 3.94 | 64.43 ± 3.73 | 61.70 ± 4.60 | 0.002 |
Baseline GLS | -19.13 ± 2.91 | -19.36 ± 2.86 | -17.51 ± 2.77 | 0.004 |
Cancer type | 0.018 | |||
Breast | 80 (42.55) | 76 (46.06) | 4 (17.39) | |
Hematologic | 99 (52.66) | 81 (49.09) | 18 (78.26) | |
Other | 9 (4.79) | 8 (4.85) | 1 (4.35) | |
Chemotherapy dose | 168.70 ± 102.91 | 175.62 ± 102.49 | 118.02 ± 93.32 | 0.013 |