Table 2 Baseline characteristic by baseline GLS [Decreased GLS defined as GLS≥(-18%)]
From: Baseline global longitudinal strain predictive of anthracycline-induced cardiotoxicity
Total N = 188 | Decreased Baseline GLS | P-value | ||
|---|---|---|---|---|
No N = 122 | Yes N = 66 | |||
Age (years) | 53.89 ± 14.40 | 53.62 ± 14.86 | 54.38 ± 13.60 | 0.73 |
Male | 62 (32.98) | 33 (27.05) | 29 (43.94) | 0.023 |
BMI (kg/m2) | 28.40 ± 6.08 | 27.53 ± 5.96 | 30.03 ± 5.99 | 0.007 |
Race | 0.91 | |||
Asian | 5 (2.66) | 4 (3.28) | 1 (1.52) | |
Black | 24 (12.77) | 14 (11.48) | 10 (15.15) | |
Caucasian | 99 (52.66) | 65 (53.28) | 34 (51.52) | |
Hispanic | 50 (26.60) | 33 (27.05) | 17 (25.76) | |
Other | 10 (5.32) | 6 (4.92) | 4 (6.06) | |
Systolic | 129.42 ± 17.68 | 127.97 ± 16.42 | 132.17 ± 19.69 | 0.13 |
Diastolic | 70.97 ± 10.66 | 69.97 ± 9.84 | 72.86 ± 11.91 | 0.083 |
Heart Rate | 76.38 ± 13.31 | 76.06 ± 12.80 | 76.95 ± 14.27 | 0.68 |
Family History of Heart Disease | 19 (10.11) | 13 (10.66) | 6 (9.09) | 0.81 |
Diabetes | 35 (18.62) | 19 (15.57) | 16 (24.24) | 0.17 |
Hypertension | 80 (42.55) | 50 (40.98) | 30 (45.45) | 0.64 |
Hyperlipidemia | 52 (27.66) | 35 (28.69) | 17 (25.76) | 0.73 |
Coronary Artery Disease | 9 (4.79) | 4 (3.28) | 5 (7.58) | 0.28 |
Hypothyroidism | 21 (11.17) | 16 (13.11) | 5 (7.58) | 0.33 |
Smoking | 48 (25.53) | 27 (22.13) | 21 (31.82) | 0.16 |
Ejection Fraction | 64.09 ± 3.94 | 65.01 ± 3.32 | 62.39 ± 4.43 | < 0.001 |
Cancer type | 0.24 | |||
Breast | 80 (42.55) | 57 (46.72) | 23 (34.85) | |
Hematologic | 99 (52.66) | 60 (49.18) | 39 (59.09) | |
Other | 9 (4.79) | 5 (4.10) | 4 (6.06) | |
Chemotherapy dose | 168.70 ± 102.91 | 165.56 ± 95.49 | 174.27 ± 115.47 | 0.58 |