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Table 2 Baseline characteristic by baseline GLS [Decreased GLS defined as GLS≥(-18%)]

From: Baseline global longitudinal strain predictive of anthracycline-induced cardiotoxicity

  Total
N = 188
Decreased Baseline GLS P-value
No
N = 122
Yes
N = 66
Age (years) 53.89 ± 14.40 53.62 ± 14.86 54.38 ± 13.60 0.73
Male 62 (32.98) 33 (27.05) 29 (43.94) 0.023
BMI (kg/m2) 28.40 ± 6.08 27.53 ± 5.96 30.03 ± 5.99 0.007
Race     0.91
 Asian 5 (2.66) 4 (3.28) 1 (1.52)  
 Black 24 (12.77) 14 (11.48) 10 (15.15)  
 Caucasian 99 (52.66) 65 (53.28) 34 (51.52)  
 Hispanic 50 (26.60) 33 (27.05) 17 (25.76)  
 Other 10 (5.32) 6 (4.92) 4 (6.06)  
Systolic 129.42 ± 17.68 127.97 ± 16.42 132.17 ± 19.69 0.13
Diastolic 70.97 ± 10.66 69.97 ± 9.84 72.86 ± 11.91 0.083
Heart Rate 76.38 ± 13.31 76.06 ± 12.80 76.95 ± 14.27 0.68
Family History of Heart Disease 19 (10.11) 13 (10.66) 6 (9.09) 0.81
Diabetes 35 (18.62) 19 (15.57) 16 (24.24) 0.17
Hypertension 80 (42.55) 50 (40.98) 30 (45.45) 0.64
Hyperlipidemia 52 (27.66) 35 (28.69) 17 (25.76) 0.73
Coronary Artery Disease 9 (4.79) 4 (3.28) 5 (7.58) 0.28
Hypothyroidism 21 (11.17) 16 (13.11) 5 (7.58) 0.33
Smoking 48 (25.53) 27 (22.13) 21 (31.82) 0.16
Ejection Fraction 64.09 ± 3.94 65.01 ± 3.32 62.39 ± 4.43 < 0.001
Cancer type     0.24
 Breast 80 (42.55) 57 (46.72) 23 (34.85)  
 Hematologic 99 (52.66) 60 (49.18) 39 (59.09)  
 Other 9 (4.79) 5 (4.10) 4 (6.06)  
Chemotherapy dose 168.70 ± 102.91 165.56 ± 95.49 174.27 ± 115.47 0.58
  1. Data were presented as mean ± SD for continuous variables and number (%) for categorical variables. Chi-square or Fisher’s exact test (categorical variables) and t-test or Mann-Whitney test (continuous variables) were used to compare patients between abnormal and normal GLS
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