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Table 3 Hazards ratio (HR) and 95% CI for developing cardiotoxicity

From: Baseline global longitudinal strain predictive of anthracycline-induced cardiotoxicity

  Univariable Multivariable
HR (95% CI) p-value HR (95% CI) p-value
GLS 1.20 (1.05,1.38) 0.01 1.17 (1.00,1.36) 0.044
GLS[≥(-18%) vs <(-18%)] 4.44 (1.83,10.8) < 0.001 3.54 (1.34,9.35) 0.011
Age 1.04 (1.01,1.07) 0.01   
Male 2.56 (1.13,5.8) 0.02   
BMI 1.01 (.94,1.08) 0.87   
Systolic 1.03 (1,1.05) 0.02 1.03 (1.01,1.05) 0.012
HR 1.01 (.97,1.04) 0.7   
LVEF 0.85 (.76,.94) < 0.001   
Caucasian 1.67 (.71,3.94) 0.24   
Family Hx of heart disease 1.99 (.68,5.86) 0.21   
Diabetes 1.76 (.69,4.49) 0.23   
HTN 3.55 (1.46,8.63) 0.01   
Hyperlipidemia 1.51 (.64,3.56) 0.35   
CAD 1.03 (.14,7.72) 0.97   
Hypothyroidism 0.34 (.05,2.53) 0.29   
Smoking 6.86 (2.9,16.21) < 0.001 5.29 (2.09,13.39) < 0.001
Breast cancer 0.24 (.08,.69) 0.01   
Chemotherapy dose 0.99 (.99,1) 0.01 0.994 (0.989,0.999) 0.018
  1. Multivariable analysis included GLS and variables selected from stepwise selection procedure. The full model included all variables with p-value< 0.05 from univariable analysis. The HR (95% CI) were presented when GLS was modeled as continuous variable. Then the same multivariable analysis was done when GLS modeled as a categorical variable [defined as ≥(-18%) vs <(-18%)]
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