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Table 3 Univariate tests for suspected CVD risk factors and drugs with possible association to CVD

From: Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma

Variable

No CVDb

CVDc

Testd

p-value

q-value

Numbera

71

22

   

Age (mean)

61.4

71.1

Mann-W

0.003

0.057

Gender = 1(%)

32 (45.1)

7 (31.8)

Chisq

0.393

0.885

DXR (mean)

493.4

417.9

Mann-W

0.121

0.436

Smoking (%)

24 (43.6)

9 (52.9)

Chisq

0.693

0.960

BMI (mean)

26.3

24.7

Mann-W

0.282

0.726

Cardiac (%)

14 (20.0)

5 (23.8)

Chisq

0.944

1.000

CVD (%)

21 (30.0)

8 (38.1)

Chisq

0.666

0.960

HT (%)

21 (30.0)

11 (52.4)

Chisq

0.105

0.436

DM(%)

9 (12.9)

4 (19.0)

Fisher

0.488

0.960

CRP (mean)

40.2 (70.9)

39.1 (53.6)

Mann-W

0.955

1.000

GFR (%)

11 (16.2)

5 (23.8)

Chisq

0.638

0.960

AB (%)

26 (36.6)

6 (27.3)

Chisq

0.583

0.960

IPIhigh (%)

22 (31.9)

7 (31.8)

Chisq

1.000

1.000

Metformin = 1(%)

7 (10.0)

2 (9.5)

Fisher

1.000

1.000

B-block (%)

10 (14.3)

6 (28.6)

Chisq

0.237

0.712

ACE/ARB (%)

14 (20.0)

10 (47.6)

Chisq

0.025

0.228

B-block/ACE-ARB (%)

19 (27.1)

11 (52.4)

Chisq

0.058

0.350

Statin (%)

16 (22.9)

6 (28.6)

Chisq

0.806

1.000

  1. Gender = 1, females; DXR,doxorubicin; Smoking, ongoing or earlier smoker; BMI, body mass index; Cardiac, cardiac disease at diagnosis, CVD, cardiovascular disease at diagnosis; HT, hypertension at diagnosis; DM, diabetes mellitus at diagnosis; CRP, c-reactive protein; GFR, glomerular filtration rate < 60 ml/min/1.72m2; AB, B-symtoms (fever, night sweats, weight loss) at diagnosis; IPIhigh, International prognostic index score ≥ 3; B-block, treatment with beta-blocker; ACE/ARB, treatment with angiotensine converting enzyme/ angiotensine II receptor blocker; Statin, treatment with statins
  2. Mann-W, Mann-Whitney test; Chisq, Chisquare test; Fisher, Fishers exact test
  3. a 93 patients included. 2 patients excluded because of lack of information on emerging CVD
  4. bNo new CVD after treatment
  5. cEmerging CVD after treatment
  6. dtype of test performed