Fig. 1From: CBR3 V244M is associated with LVEF reduction in breast cancer patients treated with doxorubicinLeft ventricular systolic function in adult breast cancer patients treated with DOX by echocardiogram at baseline and 6 months. We obtained apical two-chamber and four-chamber echocardiographic images at baseline (prior to DOX treatment; t0m) and 6 months (±2 weeks) following the initiation of DOX therapy (t6m). These images were used to calculate LVEF using Simpson’s biplane rule by investigators blinded to all patient data. The data was graphed as a violin plot showing the median (thick dashed line), quartiles (dotted line) and overall distribution of LVEF by CBR3 V244M genotype (AA, AG, GG) at t0m and t6m. p < 0.0001, two-way ANOVABack to article page