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Table 2 Complete analysis of all cardiac AE risk from immunotherapy versus chemotherapy

From: A retrospective analysis of cardiovascular adverse events associated with immune checkpoint inhibitors

Adverse Event Therapy OR (95% CI) q-value
Pericarditis Combination v chemo 0.61 (0.23, 1.67) 0.339
Combination v aCTLA4 1.79 (0.39, 8.3) 0.457
Combination v aPD1L1 0.48 (0.24, 0.97) 0.04
aPD1L1 v chemo 1.28 (0.6, 2.72) 0.523
aCTLA4 v chemo 0.34 (0.07, 1.66) 0.184
aCTLA4 v aPD1L1 0.27 (0.07, 1.1) 0.068
Myocardial Infarction Combination v chemo 0.42 (0.29, 0.6) <  0.001
Combination v aPD1L1 0.94 (0.72, 1.24) 0.671
Combination v aCTLA4 0.75 (0.5, 1.14) 0.178
aPD1L1 v chemo 0.44 (0.34, 0.58) <  0.001
aCTLA4 v chemo 0.56 (0.36, 0.85) 0.007
aCTLA4 v aPD1L1 1.25 (0.87, 1.79) 0.219
Heart Failure Combination v chemo 0.38 (0.27, 0.54) <  0.001
Combination v aPD1L1 0.84 (0.65, 1.08) 0.171
Combination v aCTLA4 2.21 (1.22, 3.9) < 0.001
aPD1L1 v chemo 0.46 (0.36, 0.59) < 0.001
aCTLA4 v chemo 0.17 (0.1, 0.32) < 0.001
aCTLA4 v aPD1L1 0.38 (0.22, 0.66) < 0.001
Coronary Artery Disease Combination v chemo 0.64 (0.37, 1.12) 0.12
Combination v aCTLA4 1.47 (0.59, 3.63) 0.405
Combination v aPD1L1 0.96 (0.6, 1.52) 0.848
aPD1L1 v chemo 0.67 (0.47, 0.96) 0.028
aCTLA4 v chemo 0.44 (0.18, 1.06) 0.066
aCTLA4 v aPD1L1 0.65 (0.28, 1.49) 0.309
Arrhythmias Combination v CTLA4 0.92 (0.7, 1.23) 0.584
Combination v chemo 0.71 (0.61, 0.84) < 0.001
Combination v aPD1L1 1.06 (0.89, 1.26) 0.531
aPD1L1 v chemo 0.67 (0.61, 0.73) < 0.001
aCTLA4 v chemo 0.77 (0.61, 0.98) 0.035
aCTLA4 v aPD1L1 1.15 (0.89, 1.47) 0.289
Myocarditis Combination v aPD1L1 1.41 (1.08, 1.85) 0.012
Combination v chemo 30.76 (18.42, 51.37) < 0.001
Combination v aCTLA4 3.93 (1.89, 8.16) < 0.001
aPD1L1 v chemo 21.81 (13.89, 34.24) < 0.001
aCTLA4 v chemo 7.83 (3.41, 18) < 0.001
aCTLA4 v aPD1L1 0.36 (0.18, 0.73) 0.005
  1. Shown is the logistic regression model data of the entire dataset, cases are not matched; Combination indicates more than one immunotherapy was administered. Adjusted p-values (q-value) is displayed
  2. aPD1L1 = anti- Programmed cell death protein - 1 and Programmed death ligand -1; aCTLA4 = cytotoxic T-lymphocyte- associated proteni 4