From: Metastatic colorectal carcinoma to the right atrium: a case report and review of the literature
Author | Age (years)/ Sex | Primary tumor site | Primary malignancy and stage | Time between initial diagnosis and discovery of cardiac metastasis (years) | Diagnostic modality of cardiac metastasis | Cardiac Site | Tumor size (cm) | Treatment | Outcome | Reference # | |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | Henuzet (1982) [13] | 60y/M | Rectum | NA | NA | TTE | RV | 2 | Resection | Dead | 13 |
2 | Nishada (1991) [14] | 69y/M | Colon | Moderately differentiated adenocarcinoma; NA | 0.66 | TTE and MRI | RA | 10 × 8 × 3 | Resection | Died 2 wk. after surgery | 14 |
3 | Massachussetts General Hospital (1992) [15] | 75y/M | Colon | NA | NA | Autopsy | RV | 7.5 × 4.5 × 4 | No | Dead | 15 |
4 | Parravicini (1993) [16] | 47y/M | Rectum | NA | 2 | Surgery | RV | 10 × 4 × 3.5 | Resection | Dead | 16 |
5 | Testempassi (1994) [17] | 71y/M | Colon | Stage III | NA | MRI | RV | NA | NA | NA | 17 |
6 | Zipoli (1994) [18] | 41y/F | Colon | M adenocarcinoma; NA | NA | TTE | RA | 4.1 × 3.7 | Resection | Died 6mo after resection of tumors | 18 |
7 | Teixeira (1997) [5] | 81y/M | Colon | Mucinous adenocarcinoma; T3N0M0 (Stage II)-Duke B2 | 5 | TTE and CT | RA | NA | Supportive | Died shortly after diagnosis of RA tumor | 5 |
8 | Lord (1999) [19] | 71y/M | Rectum | Dukes C | 3 | TTE | RV | NA | No | Dead | 19 |
9 | Choufani (2001) [6] | 59y/M | Colon | Moderately differentiated adenocarcinoma; T3N1Mx (Stage III) | 1.25 | TTE | RA | 5 × 3 | Chemotherapy-Irinotecan | Alive at 10 mo from diagnosis of RA tumor | 6 |
10 | Koizumi (2003) [20] | 65y/M | Colon | Well-differentiated adenocarcinoma; Stage III-Duke C | NA | TTE | RA | 6 × 5 | Resection | Lived for 11 mo after resection and without any chemotherapy | 20 |
11 | Oneglia (2005) [21] | 70y/F | Colon | Duke C | NA | TTE, TEE | RV, Tricuspid valve | NA | Resection | Died a few hours after surgery | 21 |
12 | Lui (2004) [22] | 71y/F | Rectum | Duke B | NA | TTE, CT scan, MRI | RV and RVOT | 5 × 3.5 | Resection | In hospital death | 22 |
13 | de la Fouchardière (2007) [12] | 70y/F | Rectum | pT3N2 | 3.5 | PET/ CT, TTE, CT scan | RV | 6 × 3 | Resection | Alive at 10 months from follow up on adjuvant chemotherapy | 12 |
14 | Moreno-Vega (2006) [23] | 70y/F | Colon | pT3N2M1 | NA | TTE, CT | RV | NA | Diagnostic pericardiocentesis | In hospital death | 23 |
15 | Choi (2009) [24] | 70y/M | Colon | Moderately differentiated adenocarcinoma; T4N2M1 (Stage IV) | 0 | TTE | RA | 5.5 × 5 × 3 | Resection | Died 3 days postoperatively secondary to recurrent cardiac bleeding | 24 |
16 | Makhija (2009) [25] | 70y/M | Rectum | Poorly differentiated mucinous adenocarcinoma; T3N2M1 (Stage IV) | 0 | TTE | RA | 5.6 (greatest diameter) | Debulking due to invasion of tumor in RA wall | Alive 4.66 years from time of diagnosis for rectal cancer | 25 |
17 | Ngow (2012) [26] | 59y/M | Colon | Dysplastic polyp in sigmoid colon with ascites/ multiple lung nodules/ ascites (no tissue confirmation of malignancy) | NA | TTE | RA | 5 × 6 | None | Died prior to therapy due to cardiac arrest | 26 |
18 | Patel (2012) [4] | 72y/M | Colon | Moderately differentiated mucinous adenocarcinoma; T4bN2bM0 (Stage III) | 3 | TTE and TEE | RA | 8.5 × 5 × 4 | None | Sudden cardiac death secondary to pulmonary embolism related to malignancy | 4 |
19 | Butler (2012) [10] | 77y/F | Rectosigmoid | Rectosigmoid well differentiated adenocarcinoma, T3N1 (Stage III) s/p surgical resection, adjuvant chemotherapy with 5-FU, levimasole and RT | 17 | CT | RA | NA | Surgery followed by chemotherapy | f/u PET/CT in 6 mo shows extension, treatment started with oxaliplatin with bevacizumab | 10 |
20 | Sudo (2013) [27] | 70y/F | Colon cancer | NA (Article in Japanese) | NA | NA | RVOT | NA | Surgery | Living 2mo after | 27 |
21 | Mihali (2013) [28] | 56y/M | Colon | Stage IV-metastatic to colon adenocarcinoma with adrenal, liver, bone, and mediastinal lymph nodes metastasis and paraneoplastic polymyositis | 0 | Autopsy | Diffuse micrometastases in myocardium | NA | NA | Death | 28 |
22 | Pontillo (2014) [7] | 70y/M | Colorectal | Colorectal adenocarcinoma s/p L hemicolectomy and chemotherapy in remission | 7 | TTE and TEE | IVC into RA, also liver | NA | Standard medical therapy | Unknown | 7 |
23 | Reisenauer (2016) [29] | 67y/M | Rectum | Stage IIIC adenocarcinoma | 1 | CT | Invasion into LA | 7.6 | Resection | Alive 1 mo post-discharge | 29 |
24 | Bianchi (2016) [9] | 77y/F | Colon | Colonic adenocarcinoma-Dukes B cancer in the descending colon s/p surgery and 6mo chemotherapy | 2 | PET/ CT and TTE | Polylobular RA mass | 4.1 × 3.5 × 3.5 | Surgical excision followed by 1 cycle of FOLFIRI and bevacizumab | Death 3 months later due to pulmonary embolism | 9 |
25 | Kasama (2016) [30] | 72y/M | Sigmoid colon | Stage IIIa later stage IV (metastatic to lungs) | NA | CT | RA | NA | Volume resection | Dead 3 months after surgery | 30 |
26 | Namireddy (2017) [11] | 51y/M | Rectal | Rectal adenocarcinoma-T3N1aM0 s/p surgery and adjuvant chemotherapy | 1 | CT and TTE | RA | 3.1 × 2.3 | Surgery followed by systemic chemotherapy | NA | 11 |
27 | Ayyala (2017) [31] | 69y/F | Rectal cancer | Rectal adenocracinoma s/p surgery and adjuvant chemotherapy | 5 | TTE | RA | 4 × 3.5 | None | NA | 31 |
28 | Tsujii (2017) [8] | 76y/F | Colorectal | Well differentiated colorectal cancer (Stage IVb: cT2N0M1b)-metastatic to heart, lung-wild type KRAS | 0 | TTE, CT and MRI | RV | 5.4 × 3.2 × 3.1 | 5-FU, oxaliplatin and panitumumab | Alive at 2 years after diagnosis | 8 |
29 | Elbatarny (2019) [32] | 59y/M | Colon cancer | Colon cancer s/p surgery and chemotherapy | 17 | TTE and cardiac MRI | RV | Occupied 80% RV | Surgical debulking | NA | 32 |
30 | Graf (2019) [33] | 70s y/M | Colon | Stage IV adenocarcinoma (metastatic to liver) | 0 | TTE and CT | RA/ RV/RVOT/Truncus pulmononalis microcavitations | microcavitations | Refused treatment | Death 4 mo after diagnosis | 33 |
31 | Current | 59y/M | Colon | NA | 5 | TTE and cMRI | RA | 8.3 × 6.5 | Chemotherapy | Alive |