Fig. 1

Progression of cardiac magnetic resonance parameters in mice exposed to doxorubicin with and without cardioprotection. We observed main differences at week 12 in ECV, GCS, GLS, LVEF and RVEF between the DOX/DEX (orange bars) and control group (gray bars) compared to the DOX group (blue bars). * indicates an adjusted p-value < 0.05 for DOX compared to control group, # indicates an adjusted p-value < 0.05 for both DOX and DOX/DEX compared to control group, $ indicates an adjusted p-value < 0.05 for DOX compared to both DOX/DEX and control group, ## indicated an adjusted p-value < 0.05 for all three groups compared to one another. CMR = cardiac magnetic resonance, Control = saline solution, DOX = doxorubicin, DOX/DEX = doxorubicin plus dexrazoxane, ECV = extracellular volume, GCS = global circumferential strain, GLS = global longitudinal strain, LVEF = left ventricular ejection fraction, RVEF = right ventricular ejection fraction, T2 Avg = T2 average