Table 1 Parameter Difference with Statistical Significance Between Treatments with Time. * Denotes significant difference between DOX and control; # denotes significant difference between DOX and DOX/DEX; $ Denotes significant difference between DOX/DEX and control
Parameter | Average ± Std | Average ± Std | Average ± Std |
|---|---|---|---|
WEEK 4 | |||
 LV Volume (μL) | 114.8 ± 8.99* | 117.5 ± 7.59# | 104.83 ± 6.68 |
 LV Mass (μg) | 80.07 ± 8.58 | 86.4 ± 6.82 | 80.17 ± 7.28 |
 LVEF | 53.93 ± 4.01 * | 55.3 ± 3.97 | 59.17 ± 3.37 |
 RVEF | 50.27 ± 4.15 * | 50.5 ± 2.12# | 59 ± 2.0 |
 GLS | - 9.29 ± 2.09 * | - 10.73 ± 1.23 | −12.72 ± 1.33 |
 T1 Pre (msec) | 1283.27 ± 127.96 | 1288.4 ± 81.86 | 1261.17 ± 47.27 |
 T1 Post (msec) | 576.33 ± 53.31 | 568.1 ± 52.09 | 548.17 ± 37.03 |
 ECV | 0.27 ± 0.02 | 0.26 ± 0.01 | 0.26 ± 0.01 |
 T2 Avg (msec) | 30.47 ± 3.38 * | 27.2 ± 2.35# | 23.17 ± 1.47$ |
 Mass.Vol | 0.7 ± 0.04 | 0.74 ± 0.08 | 0.77 ± 0.09 |
WEEK 8 | |||
 LV Volume (μL) | 132.8 ± 7.0 * | 133.8 ± 6.18# | 116.67 ± 7.42 |
 LV Mass (μg) | 89.53 ± 17.66 | 102 ± 8.77 | 93.5 ± 9.09 |
 LVEF | 48.2 ± 7.52 * | 52.6 ± 3.57 | 59.17 ± 1.83 |
 RVEF | 43.53 ± 9.33 * | 49 ± 5.98 | 57.67 ± 4.13 |
 GLS | - 8.55 ± 1.93 * | - 9.29 ± 1.52# | - 12.83 ± 1.12 |
 T1 Pre (msec) | 1327.67 ± 85.76 | 1280.6 ± 83.97 | 1252.17 ± 58.53 |
 T1 Post (msec) | 539.47 ± 43.69 | 565.9 ± 37.5 | 565.67 ± 39.07 |
 ECV | 0.29 ± 0.03 * | 0.26 ± 0.01 | 0.26 ± 0.01$ |
 T2 Avg (msec) | 27.13 ± 1.96 * | 26.4 ± 1.07# | 24 ± 1.1 |
 Mass.Vol | 0.67 ± 0.12 * | 0.76 ± 0.06 | 0.81 ± 0.1 |
WEEK 12 | |||
 LV Volume (μL) | 141.27 ± 7.6 * | 139.7 ± 8.55# | 129.17 ± 3.92 |
 LV Mass (μg) | 95.2 ± 24.83 | 115.5 ± 10.33 | 101.5 ± 5.54$ |
 LVEF | 39.67 ± 6.88 * | 51 ± 5.37 | 57.67 ± 3.08$ |
 RVEF | 40.73 ± 8.63 * | 47.2 ± 6.58 | 54.83 ± 4.07 |
 GLS | - 7.37 ± 1.97 * | - 9.6 ± 1.86 | - 12.0 ± 1.78$ |
 T1 Pre (msec) | 1298.53 ± 77.38 | 1276.4 ± 77.59 | 1260.83 ± 43.78 |
 T1 Post (msec) | 532.2 ± 50.34 | 543.3 ± 56.02 | 566.33 ± 52.99 |
 ECV | 0.32 ± 0.04 * | 0.28 ± 0.03 | 0.27 ± 0.02$ |
 T2 Avg (msec) | 24.6 ± 1.76 | 23.9 ± 1.1 | 25.0 ± 1.55 |
 Mass.Vol | 0.68 ± 0.19 * | 0.83 ± 0.11 | 0.79 ± 0.06$ |