Variables | Sample | Treatment | P-value | |||
---|---|---|---|---|---|---|
N = 30,195,722 | MM (n = 4,640,563 [99.60%]) | TAVR (n = 9318 [0.20%]) | SAVR (n = 8852 [0.19%]) | TAVR versus MM | TAVR vs SAVR | |
Demographics, no. (%) | ||||||
Age, mean (SD) | 68.70 (14.30) | 68.67 (14.31) | 81.00 (7.93) | 71.52 (9.35) | < 0.001 | < 0.001 |
Female | 15,254,879 (50.52) | (50.54) | (40.2) | (32.61) | < 0.001 | < 0.001 |
Race, nonwhite | 7,132,230 (23.62) | (23.65) | (10.00) | (10.97) | < 0.001 | 0.349 |
Insurance, non-private | 23,380,548 (77.43) | (77.4) | (93.23) | (79.23) | < 0.001 | < 0.001 |
Medical history | ||||||
Diabetes | 6247,495 (20.69) | (20.68) | (26.02) | (20.20) | < 0.001 | < 0.001 |
Hypertension | 19,790,276 (65.54) | (65.49) | (88.13) | (81.14) | < 0.001 | < 0.001 |
Hyperlipidemia | 11,869,938 (39.31) | (39.25) | (69.29) | (70.20) | < 0.001 | 0.546 |
Congestive heart failure | 1,926,487 (6.38) | (6.33) | (34.3) | (12.95) | < 0.001 | < 0.001 |
Smoking | 332,153 (1.10) | (1.10) | (0.37) | (1.17) | < 0.001 | 0.005 |
Depression | 3,895,248 (12.90) | (12.91) | (7.6) | (9.43) | < 0.001 | 0.046 |
Cirrhosis | 742,815 (2.46) | (2.47) | (1.53) | (0.56) | 0.009 | 0.004 |
CKD 3–5 | 4,055,285 (13.43) | (13.4) | (24.54) | (11.55) | < 0.001 | < 0.001 |
Outcomes, median (range) | ||||||
Mortality, no. (%) | 1,201,790 (3.98) | (3.99) | (1.43) | (3.24) | < 0.001 | < 0.001 |
Length of stay, days | 5.46 (6.34) | 5.45 (6.34) | 4.59 (4.56) | 9.10 (7.09) | < 0.001 | < 0.001 |
Cost, dollars | 60,612.22 (87,774.68) | 60,002.30 (86,913.86) | 210,106.90 (110,707.70) | 219,202.30 (179,519.90) | < 0.001 | 0.065 |