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Table 2 Propensity score adjusted multivariable regression of outcomes by aortic valve replacement versus medical management for cancer and non-cancer patientsa

From: TAVR and cancer: machine learning-augmented propensity score mortality and cost analysis in over 30 million patients

Variable

OR (95%CI; p-value)

Mortality

Cost (United States Dollars)

Length of stay (Days)

Age by 10 years

TAVR vs MM

TAVR vs SAVR

TAVR vs MM

TAVR vs SAVR

TAVR vs MM

TAVR vs SAVR

Non-white race

1.01 (1.01–1.01)

1.00 (1.00–1.01)

−43.90 (−47.04- -40.76)

−3.66 (− 192.18–184.84)

− 0.02 (− 0.02- -0.02)

−0.06 (− 0.07- -0.05)

Zip code income

1.03 (1.02–1.04)

0.98 (0.78–1.23)

3953.27 (3833.21-4073.34)

31,486.94 (25,653.33-37,320.55)

0.31 (0.30–0.32)

1.12 (0.84–1.40)

1st quartile

Reference

Reference

Reference

Reference

Reference

Reference

2nd quartile

0.96 (0.95–0.98)

0.91 (0.71–1.16)

2120.83 (1976.57-2265.09)

4416.36 (− 1564.70-10,397.41)

− 0.13 (− 0.15- -0.12)

−0.20 (− 0.49–0.09)

3rd quartile

0.92 (0.90–0.93)

0.98 (0.77–1.25)

5372.67 (5224.71-5520.64)

16,506.95 (10,558.02-22,455.89)

−0.17 (− 0.18- -0.16)

−0.49 (− 0.78- -0.20)

4th quartile

0.93 (0.91–0.95)

0.92 (0.71–1.19)

9909.08 (9751.90-10,066.26)

31,220.53 (25,154.54-37,246.52)

−0.11 (− 0.12- -0.09)

−0.25 (− 0.54–0.04)

Procedure

0.52 (0.43–0.63)

0.90 (0.70–1.16)

164,413 (162,704.90-166,121.10)

52,098.41 (46,359.88-57,836.93)

−0.01 (− 0.17–0.14)

− 3.85 (− 4.13- -3.58)

Malignancy

1.08 (1.06–1.10)

1.07 (0.78–1.47)

2606.99 (2441.96-2772.02)

− 7911.60 (− 15,835.76–12.55)

0.06 (0.05–0.08)

− 0.89 (− 1.27- -0.51)

Metastases

1.95 (1.91–2.00)

0.63 (0.15–2.70)

− 6706.27 (− 7033.93- -6378.60)

922.71 (− 575.25–22,025.82)

− 0.31 (− 0.34- -0.28)

0.86 (− 0.81–2.54)

With Procedure

0.71 (0.45–1.11)

0.76 (0.43–1.32)

−5186.04 (− 8627.01- -1745.08)

10,725.28 (− 575.25–22,025.82)

− 0.72 (− 1.04- -0.40)

0.35 (− 0.20–0.89)

Mortality risk by DRG

7.88 (7.81–7.96)

10.74 (8.93–12.93)

8108.62 (8042.55-8174.68)

21,602.97 (18,898.19-24,307.74)

2.10 (2.09–2.10)

4.29 (4.18–4.41)

Length of stay, days

  

7514.37 (7505.36-7523.38)

14,544.34 (14,262.47-14,826.21)

  
  1. aTAVR transcatheter aortic valve replacement, MM medical management, SAVR surgical aortic valve replacement, DRG Disease Related Group, bold = statistically significant