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Table 3 Cardiovascular disease and cancer history association with major complications in patients with symptomatic COVID-19 admissions

From: Impact of cancer and cardiovascular disease on in-hospital outcomes of COVID-19 patients: results from the american heart association COVID-19 cardiovascular disease registry

Outcome of interest Univariable Analysis Multivariable analysis
OR 95% CI p value OR 95% CI p value
Mace
  CVD History 2.06 1.69 – 2.50  < 0.001 1.32 1.05 – 1.67 0.018
  Cancer Historya 1.63 1.26 – 2.11  < 0.001    
  Among Males     0.85 0.65 – 1.12 0.26
  Among Females     1.59 1.02 – 2.48 0.039
Severe Disease Complication
  CVD History 1.26 1.12 – 1.41  < 0.0001 0.91 0.78 – 1.07 0.26
  Cancer Historyb 1.15 0.99 – 1.34 0.062    
  Among Smokersc     2.76 1.98 – 3.86  < 0.001
  Among Non-Smokerc     1.12 0.91 – 1.37 0.29
Thromboembolic Event
  CVD History 1.01 0.73 – 1.38 0.97 0.93 0.68 – 1.28 0.653
  Cancer History 1.21 0.82 – 1.80 0.34 0.86 0.55 – 1.32 0.482
  1. All multivariable models were adjusted for age, gender, body mass index, race, diabetes, hypertension, hyperlipidemia, smoking history, chronic kidney disease, and pulmonary disease
  2. CVD Cardiovascular Disease
  3. aThe following interaction term is found to be significant in the multivariable logistic regression analysis for the outcome of MACE and retained in the final model: Gender*Cancer History (p = 0.03)
  4. b The following interaction terms are found to be significant in the multivariable logistic regression analysis for the outcome of severe disease complications and retained in the final model: Age*Cancer History (p = 0.01) and Smoking History*Cancer History (p = 0.003)
  5. c Evaluated at an average age (61.5 years) in the study cohort