Impact of cancer and cardiovascular disease on in-hospital outcomes of COVID-19 patients: results from the american heart association COVID-19 cardiovascular disease registry

Table 3 Cardiovascular disease and cancer history association with major complications in patients with symptomatic COVID-19 admissions

Outcome of interest	Univariable Analysis			Multivariable analysis
Outcome of interest	OR	95% CI	p value	OR	95% CI	p value
Mace
CVD History	2.06	1.69 – 2.50	< 0.001	1.32	1.05 – 1.67	0.018
Cancer History^a	1.63	1.26 – 2.11	< 0.001
Among Males				0.85	0.65 – 1.12	0.26
Among Females				1.59	1.02 – 2.48	0.039
Severe Disease Complication
CVD History	1.26	1.12 – 1.41	< 0.0001	0.91	0.78 – 1.07	0.26
Cancer History^b	1.15	0.99 – 1.34	0.062
Among Smokers^c				2.76	1.98 – 3.86	< 0.001
Among Non-Smoker^c				1.12	0.91 – 1.37	0.29
Thromboembolic Event
CVD History	1.01	0.73 – 1.38	0.97	0.93	0.68 – 1.28	0.653
Cancer History	1.21	0.82 – 1.80	0.34	0.86	0.55 – 1.32	0.482

All multivariable models were adjusted for age, gender, body mass index, race, diabetes, hypertension, hyperlipidemia, smoking history, chronic kidney disease, and pulmonary disease
CVD Cardiovascular Disease
^aThe following interaction term is found to be significant in the multivariable logistic regression analysis for the outcome of MACE and retained in the final model: Gender*Cancer History (p = 0.03)
^b The following interaction terms are found to be significant in the multivariable logistic regression analysis for the outcome of severe disease complications and retained in the final model: Age*Cancer History (p = 0.01) and Smoking History*Cancer History (p = 0.003)
^c Evaluated at an average age (61.5 years) in the study cohort

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