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Table 3 Sensitivity analysis displaying multivariablea hazard ratios (HRs), stratified by age quartiles

From: Increased risk of non-hematological cancer in young patients with aortic stenosis: a retrospective cohort study

Age quartiles

Adjustment for additional variablesb

(n = 105,897)

HR (95% CI)

Patients without prior malignancyc

(n = 87,172)

HR (95% CI)

One year landmark analysisd

(n = 95,930)

HR (95% CI)

Lowest quartile

(20–49.7 years)

1.86 (1.04–3.30)

2.24 (1.06–4.71)

1.71 (0.88–3.31)

Second quartile

(49.7–63 years)

1.14 (0.88–1.48)

0.91 (0.63–1.32)

1.22 (0.93–1.62)

Third quartile

(63–74.7 years)

0.95 (0.82–1.11)

0.96 (0.79–1.16)

1.03 (0.88–1.22)

Highest quartile

(> 74.7 years)

1.02 (0.92–1.13)

0.96 (0.85–1.09)

1.02 (0.90–1.16)

  1. aAdjusted for age (continuous variable), sex, ethnicity, socioeconomic status, smoking, alcohol abuse, obesity, diabetes mellitus, previous history of cancer (except for patients without prior malignancy analysis) and aspirin and statin use
  2. bIn addition to the above variables, additional adjustment was performed for heart failure, ischemic heart disease, peripheral vascular disease, previous stroke, atrial fibrillation, and year of study entry
  3. cWithout prior malignancy of any type (hematological and non-hematological)
  4. d The landmark analysis excluded patients with cancer diagnosed in the first year and was restricted to patients with follow up greater than one year
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Cardio-Oncology

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