Table 3 Significant univariable predictors of new onset cardiac complication outcome and all-cause mortality before and after 1:2 propensity score matching

Demographics

Male gender

0.98[0.87-1.10];0.6878

1.00[0.78-1.29];0.9898

1.03[0.83-1.29];0.7733

1.12[0.67-1.88];0.6546

Female gender

1.0[Reference]

1.0[Reference]

1.0[Reference]

1.0[Reference]

Baseline age, years

1.00[1.00-1.01];0.1533

1.01[1.01-1.02];0.0016**

1.01[1.00-1.01];0.2976

1.00[0.98-1.02];0.9421

<40

1.0[Reference]

1.0[Reference]

1.0[Reference]

1.0[Reference]

[40, 50)

1.02[0.85-1.22];0.8400

0.72[0.46-1.12];0.1450

1.07[0.73-1.56];0.7308

0.96[0.39-2.38];0.9321

[50-60)

1.04[0.92-1.18];0.5569

0.97[0.74-1.28];0.8386

0.87[0.69-1.09];0.2345

1.20[0.74-1.95];0.4528

[60-70)

1.02[0.91-1.14];0.7455

1.05[0.82-1.35];0.6880

0.98[0.81-1.19];0.8684

0.71[0.45-1.11];0.1309

[70-80)

0.98[0.85-1.12];0.7150

1.19[0.91-1.57];0.2103

1.16[0.92-1.47];0.2172

1.13[0.66-1.96];0.6528

>=80

1.07[0.86-1.35];0.5366

1.40[0.89-2.21];0.1436

1.03[0.63-1.70];0.9074

1.51[0.55-4.13];0.4210

Past comorbidities

Charlson’s standard comorbidity index

1.05[1.04-1.07];<0.0001***

1.08[1.04-1.12];<0.0001***

1.08[1.04-1.11];<0.0001***

1.07[1.00-1.15];0.0589

Hypertension

1.20[1.02-1.40];0.0262*

1.11[0.78-1.59];0.5645

1.32[1.00-1.73];0.0481*

1.18[0.61-2.29];0.6236

Liver diseases

1.24[1.04-1.47];0.0163*

0.77[0.49-1.22];0.2689

1.46[0.91-2.35];0.1148

1.32[0.42-4.18];0.6381

Hip fractures/accident falls

1.26[0.96-1.64];0.0910

1.98[1.21-3.23];0.0065**

0.79[0.50-1.25];0.3174

2.21[1.10-4.41];0.0253*

Renal diseases

1.02[0.88-1.19];0.7670

1.06[0.77-1.48];0.7155

1.05[0.79-1.39];0.7571

1.24[0.67-2.29];0.4871

Diabetes mellitus

1.13[0.92-1.37];0.2369

1.05[0.67-1.66];0.8204

1.12[0.80-1.57];0.4963

1.12[0.52-2.43];0.7733

Malignant dysrhythmia

2.09[1.12-3.89];0.0206*

11.11[5.88-20.98];<0.0001***

0.00[0.00-Inf];0.9877

0.00[0.00-Inf];0.9946

Chronic obstructive pulmonary disease

1.42[0.78-2.56];0.2515

1.83[0.59-5.72];0.2971

2.04[0.84-4.94];0.1133

5.51[1.34-22.64];0.0179*

Ischemic heart disease

0.98[0.72-1.34];0.8984

1.30[0.69-2.44];0.4160

0.98[0.49-1.98];0.9639

0.70[0.10-5.07];0.7271

Peripheral vascular disease

1.10[0.57-2.12];0.7774

1.93[0.62-6.03];0.2570

0.87[0.22-3.51];0.8502

2.51[0.35-18.07];0.3611

Endocrine diseases

1.04[0.93-1.18];0.4907

0.76[0.58-1.00];0.0538

1.04[0.84-1.29];0.7304

0.75[0.44-1.28];0.2934

Gastrointestinal diseases

1.03[0.92-1.17];0.5810

0.94[0.73-1.21];0.6327

1.22[0.93-1.59];0.1534

1.71[0.85-3.41];0.1296

Stroke/transient ischemic attack

1.11[0.85-1.46];0.4279

1.02[0.54-1.92];0.9477

1.48[0.91-2.40];0.1149

0.96[0.24-3.92];0.9586

Hospitalization

Average readmission

1.000[1.000-1.000];0.2724

0.998[0.997-1.000];0.0625

1.000[1.000-1.001];0.0823

0.99[0.98-1.00];0.0080**

Total episode number

0.95[0.95-0.96];<0.0001***

0.96[0.95-0.97];<0.0001***

0.96[0.95-0.97];<0.0001***

0.97[0.95-0.99];0.0050**

Overall hospital stay, days

1.001[0.999-1.002];0.3779

1.001[0.999-1.004];0.3117

1.00[1.00-1.01];0.0004***

1.01[1.00-1.01];0.0040**

Medications

PD-L1 v.s. PD-1

0.77[0.64-0.93];0.0078**

0.32[0.18-0.59];0.0002***

0.80[0.65-1.00];0.0463*

0.34[0.18-0.65];0.0010**

PD-L1 expenditure, HKD

1.000[1.000-1.0001];<0.0001***

1.000[1.000-1.000];0.0528

1.000[1.000-1.0001];<0.0001***

1.000[1.000-1.000];0.0528

Total PD-L1 dose amount, mg

1.000[1.000-1.000];0.0703

1.000[1.000-1.000];0.2410

1.000[1.000-1.000];0.0703

1.000[1.000-1.000];0.2410

PD-L1 inhibitors duration, days

1.00[0.99-1.001];<0.0001***

0.99[0.99-1.00];0.0263*

1.00[0.99-1.00];<0.0001***

0.99[0.99-1.00];0.0263*

PD-1 expenditure, HKD

1.000[1.000-1.0001];<0.0001***

1.000[1.000-1.0001];<0.0001***

1.000[1.000-1.0001];<0.0001***

1.000[1.000-1.001];0.0018**

Total PD-1 dose amount (mg)

1.000[1.000-1.0001];<0.0001***

1.000[1.000-1.000];0.1842

1.000[1.000-1.0001];0.0008***

1.000[1.000-1.000];0.0958

PD-1 inhibitors duration, days

0.997[0.997-0.998];<0.0001***

0.998[0.997-0.998];<0.0001***

0.998[0.997-0.998];<0.0001***

0.998[0.997-0.999];0.0007***

Anticoagulants

0.81[0.73-0.91];0.0002***

0.73[0.58-0.93];0.0097**

0.89[0.74-1.08];0.2423

0.78[0.50-1.20];0.2574

Steroids

0.81[0.73-0.91];0.0002***

0.73[0.58-0.93];0.0097**

0.89[0.74-1.08];0.2423

0.78[0.50-1.20];0.2574

Biomarkers

Neutrophil-to-lymphocyte ratio

1.01[1.00-1.01];0.0296*

1.00[0.98-1.02];0.8231

1.01[1.00-1.02];0.1025

0.97[0.92-1.03];0.3646

Platelet-to-lymphocyte ratio

1.000[1.000-1.000];0.0261*

1.000[1.000-1.001];0.5907

1.000[1.000-1.000];0.1087

1.000[0.999-1.001];0.9257

Aspartate transaminase-to-alanine transaminase ratio

1.03[1.01-1.04];<0.0001***

1.01[0.97-1.06];0.6492

1.09[1.04-1.14];0.0004***

0.96[0.71-1.29];0.7683

Triglyceride glucose index

0.97[0.83-1.13];0.6770

0.59[0.41-0.85];0.0040**

0.85[0.66-1.09];0.2061

0.55[0.30-1.02];0.0594

Urea-to-creatinine ratio

1.000[0.999-1.001];0.9657

1.000[0.997-1.002];0.9081

1.00[1.00-1.01];0.2003

1.01[1.00-1.01];0.0007***

Monocyte-to-lymphocyte ratio

1.07[0.99-1.16];0.0998

0.99[0.79-1.23];0.9303

1.20[1.02-1.43];0.0305*

1.07[0.69-1.67];0.7559

Complete blood counts

Hb, g/dL

0.97[0.95-1.00];0.0539

1.00[0.94-1.06];0.9969

0.95[0.91-1.00];0.0543

1.19[1.05-1.34];0.0072**

SD of Hb

1.58[1.44-1.74];<0.0001***

1.51[1.23-1.85];0.0001***

1.52[1.29-1.79];<0.0001***

1.94[1.36-2.76];0.0003***

Mean corpuscular volume, fL

1.00[0.99-1.01];0.9942

1.01[1.00-1.03];0.1496

1.00[0.98-1.01];0.5845

1.03[1.00-1.07];0.0470*

Eosinophil, x10^9/L

0.74[0.58-0.93];0.0105*

0.84[0.54-1.31];0.4333

0.81[0.53-1.23];0.3143

1.14[0.49-2.64];0.7632

Lymphocyte, x10^9/L

0.98[0.92-1.05];0.6221

1.08[0.97-1.20];0.1514

0.96[0.83-1.10];0.5296

1.07[0.78-1.47];0.6699

Metamyelocyte, x10^9/L

0.87[0.70-1.07];0.1830

0.78[0.46-1.31];0.3392

0.71[0.40-1.28];0.2549

0.74[0.21-2.63];0.6383

Monocyte, x10^9/L

1.24[1.06-1.45];0.0078**

1.23[0.87-1.73];0.2362

1.51[1.14-2.00];0.0045**

1.65[0.88-3.11];0.1194

Neutrophil, x10^9/L

1.02[1.01-1.04];0.0013**

1.01[0.98-1.05];0.4025

1.03[1.01-1.06];0.0129*

1.02[0.96-1.08];0.5817

White blood count, x10^9/L

1.02[1.01-1.03];<0.0001***

1.02[1.00-1.05];0.1069

1.03[1.00-1.05];0.0187*

1.02[0.97-1.08];0.4938

Mean cell haemoglobin, pg

0.99[0.97-1.01];0.2267

1.01[0.97-1.05];0.6190

0.96[0.94-0.99];0.0133*

1.05[0.97-1.14];0.1981

Myelocyte, x10^9/L

0.93[0.84-1.02];0.1131

0.88[0.66-1.18];0.3893

0.83[0.66-1.04];0.1098

0.83[0.50-1.39];0.4823

Platelet, x10^9/L

1.001[1.000-1.001];0.0388*

1.001[1.000-1.002];0.2819

1.002[1.001-1.003];0.0015**

1.002[0.999-1.004];0.1452

Red blood count, x10^12/L

0.93[0.86-1.01];0.0818

0.93[0.78-1.10];0.3688

0.91[0.79-1.06];0.2409

1.26[0.89-1.78];0.1925

Hematocrit, L/L

0.30[0.11-0.80];0.0163*

0.75[0.09-6.67];0.7997

0.18[0.03-1.13];0.0671

566.25[4.88-65751.46];0.0090**

Renal and liver functions

Potassium, mmol/L

0.91[0.80-1.03];0.1211

1.03[0.79-1.35];0.8120

0.87[0.69-1.09];0.2157

0.92[0.56-1.52];0.7440

Urate, mmol/L

1.54[0.72-3.30];0.2671

5.04[0.95-26.62];0.0570

1.71[0.32-9.18];0.5314

0.65[0.02-19.52];0.8040

Albumin, g/L

0.97[0.96-0.98];<0.0001***

0.98[0.96-1.00];0.0540

0.98[0.96-0.99];0.0061**

1.04[0.99-1.09];0.1011

Sodium, mmol/L

0.97[0.96-0.98];<0.0001***

0.97[0.95-1.00];0.0227*

0.95[0.92-0.97];0.0001***

0.97[0.91-1.05];0.4786

Urea, mmol/L

0.99[0.97-1.02];0.5540

1.02[0.98-1.06];0.4164

0.98[0.93-1.03];0.4672

1.00[0.89-1.13];0.9939

Protein, g/L

0.99[0.99-1.00];0.0001***

1.00[0.99-1.01];0.8901

0.99[0.99-1.00];0.0087**

1.00[0.98-1.02];0.9227

Bilirubin, umol/L

1.003[1.002-1.005];<0.0001***

1.00[1.00-1.01];0.5730

1.00[1.00-1.01];0.9330

1.00[0.99-1.01];0.9730

Creatinine, umol/L

1.001[1.000-1.001];0.2210

1.000[0.998-1.002];0.7707

1.001[0.999-1.002];0.2969

1.00[0.99-1.00];0.4195

SD of creatinine

1.001[1.000-1.001];0.0001***

1.001[1.000-1.002];0.0719

1.001[1.000-1.001];0.0974

1.000[0.998-1.002];0.7760

Aspartate transaminase, U/L

1.001[1.001-1.001];<0.0001***

1.000[0.998-1.002];0.8846

1.001[0.999-1.002];0.4383

0.99[0.98-1.01];0.2798

SD of aspartate transaminase

1.001[1.000-1.001];<0.0001***

1.000[1.000-1.001];0.2117

1.001[1.000-1.002];0.0155*

1.001[0.997-1.004];0.6500

Alkaline phosphatase, U/L

1.001[1.001-1.002];<0.0001***

1.000[0.999-1.002];0.7097

1.000[0.999-1.001];0.4551

1.00[0.99-1.00];0.2454

SD of alkaline phosphatase

1.002[1.002-1.003];<0.0001***

1.002[1.001-1.003];0.0014**

1.003[1.002-1.003];<0.0001***

1.002[1.000-1.004];0.0359*

Alanine transaminase, U/L

1.000[1.000-1.001];0.3737

1.000[0.998-1.002];0.8684

0.999[0.995-1.002];0.3897

0.99[0.98-1.00];0.0914

SD of alanine transaminase

1.001[1.001-1.002];<0.0001***

1.001[1.000-1.002];0.0177*

1.001[1.000-1.003];0.0741

1.00[0.99-1.00];0.5347

Lipid, iron, and calcium profile

Total iron-binding capacity, L

1.00[0.98-1.02];0.9971

1.00[0.95-1.05];0.9678

0.99[0.95-1.04];0.7518

3.87[0.00-Inf];0.9993

VitaminB12, pmol/L

0.999[0.998-1.000];0.1739

1.00[0.99-1.00];0.1813

1.000[0.998-1.002];0.7853

1.00[0.99-1.01];0.8806

Folate, ng/mL

1.00[0.97-1.03];0.9877

1.04[0.97-1.12];0.2752

1.00[0.96-1.05];0.8835

1.04[0.95-1.14];0.3791

Ferritin, pmol/L

1.000[1.000-1.000];0.4438

1.000[1.000-1.000];0.3647

1.000[1.000-1.000];0.2525

1.000[1.000-1.001];0.1003

Calcium, mmol/L

0.64[0.39-1.06];0.0826

0.41[0.13-1.26];0.1212

0.91[0.36-2.28];0.8345

1.40[0.20-9.84];0.7350

SD of calcium

12.70[5.21-30.97];<0.0001***

2.10[0.13-34.34];0.6015

4.69[1.00-22.02];0.0499*

2.32[0.04-132.03];0.6840

Phosphate, mmol/L

0.83[0.59-1.18];0.3059

0.79[0.36-1.74];0.5548

0.98[0.50-1.90];0.9464

0.61[0.14-2.69];0.5115

SD of phosphate

5.97[3.23-11.04];<0.0001***

7.44[1.81-30.57];0.0054**

3.91[0.74-20.76];0.1098

18.22[0.41-815.46];0.1345

Glycemic and clotting profile

Triglyceride, mmol/L

0.96[0.88-1.05];0.3264

0.74[0.56-0.99];0.0436*

0.90[0.78-1.04];0.1556

0.61[0.35-1.09];0.0933

SD of triglyceride

0.84[0.64-1.11];0.2196

0.20[0.04-1.02];0.0526

0.69[0.41-1.17];0.1655

0.54[0.08-3.53];0.5213

Glucose, mmol/L

1.02[0.99-1.04];0.1738

1.00[0.94-1.05];0.9179

0.99[0.95-1.03];0.5861

0.90[0.79-1.04];0.1558

SD of glucose

1.06[1.02-1.11];0.0032**

1.07[0.98-1.16];0.1337

1.07[1.00-1.14];0.0580

1.07[0.92-1.23];0.3816

High sensitive troponin-I, ng/L

1.000[1.000-1.000];0.9239

1.000[1.000-1.000];0.1181

1.000[1.000-1.000];0.9382

1.000[1.000-1.001];0.1785

SD of high sensitive troponin-I

1.000[1.000-1.000];0.7182

1.000[1.000-1.000];0.0044**

1.000[0.999-1.001];0.9978

1.000[1.000-1.001];0.2563

APTT, second

1.01[1.00-1.03];0.1426

0.98[0.93-1.03];0.3733

0.99[0.95-1.03];0.6325

0.98[0.89-1.08];0.6750

SD of APTT

1.05[1.02-1.08];0.0006***

0.99[0.90-1.10];0.8880

1.01[0.90-1.13];0.8927

1.10[0.86-1.42];0.4432

Lactate dehydrogenase, U/L

1.000[1.000-1.000];<0.0001***

1.000[1.000-1.001];0.0165*

1.000[1.000-1.001];0.0001***

1.000[0.999-1.001];0.6208

SD of lactate dehydrogenase

1.000[1.000-1.000];<0.0001***

1.000[1.000-1.001];0.0229*

1.002[1.001-1.002];<0.0001***

1.002[1.000-1.003];0.0056**

Total cholesterol, mmol/L

0.98[0.90-1.07];0.6769

0.92[0.75-1.13];0.4335

1.05[0.90-1.22];0.5598

1.42[1.00-2.00];0.0490*

SD of total cholesterol

1.14[0.84-1.55];0.3905

0.93[0.42-2.07];0.8677

1.23[0.73-2.07];0.4394

2.73[0.81-9.19];0.1058

Low-density lipoprotein, mmol/L

1.00[0.90-1.11];0.9905

0.96[0.76-1.22];0.7514

1.14[0.96-1.37];0.1398

1.67[1.14-2.45];0.0091**

SD of low-density lipoprotein

1.22[0.84-1.78];0.2952

1.13[0.45-2.83];0.7919

1.66[0.77-3.55];0.1928

7.64[1.84-31.77];0.0051**

High-density lipoprotein, mmol/L

0.93[0.73-1.19];0.5774

1.27[0.77-2.11];0.3530

0.97[0.62-1.50];0.8772

1.96[0.82-4.71];0.1309

SD of high-density lipoprotein

2.42[0.85-6.87];0.0971

1.55[0.11-21.84];0.7461

1.32[0.19-9.12];0.7758

1.09[0.01-164.28];0.9719