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Table 4 Comparisons of hospitalization characteristics before and after PD1/PD-L1 treatment in patients with new onset heart failure, acute myocardial infarction, atrial fibrillation, and atrial flutter

From: Adverse Cardiovascular Complications following prescription of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: a propensity-score matched Cohort Study with competing risk analysis

Hospitalization characteristics

Before matching

  

After 1:1 matching

  

Before treatment

Mean(SD);N or Count(%)

After treatment

Mean(SD);N or Count(%)

P value

Before treatment

Mean(SD);N or Count(%)

After treatment

Mean(SD);N or Count(%)

P value

Heart failure (N = 244)

Heart failure (N = 75)

  

Average readmission interval between episodes, days

299.3(680.4);n = 202

45.5(95.9);n = 244

<0.0001***

358.6(922.4);n = 61

38.1(45.2);n = 75

<0.0001***

No. of episodes

8.8(7.4);n = 202

13.8(12.3);n = 244

<0.0001***

11.0(7.8);n = 61

12.9(9.5);n = 75

<0.0001***

Hospital stay, days

26.6(35.0);n = 202

40.6(36.0);n = 244

<0.0001***

33.7(38.8);n = 61

39.9(39.6);n = 75

<0.0001***

Acute myocardial infarction (N = 38)

Acute myocardial infarction (N = 8)

Average readmission interval between episodes, days

498.3(1094.7);n = 32

42.1(53.5);n = 38

<0.0001***

1576.1(2728.8);n = 6

38.9(16.4);n = 8

<0.0001***

No. of episodes

6.4(5.7);n = 32

13.2(8.9);n = 38

<0.0001***

5.8(3.9);n = 6

17.4(11.6);n = 8

<0.0001***

Hospital stay, days

24.5(28.9);n = 32

34.3(30.4);n = 38

<0.0001***

11.5(6.4);n = 6

20.8(12.3);n = 8

<0.0001***

Atrial fibrillation (N = 54)

Atrial fibrillation (N = 8)

Average readmission interval between episodes, days

383.9(905.9);n = 46

43.4(48.0);n = 54

<0.0001***

715.5(1861.5);n = 6

49.4(45.0);n = 8

<0.0001***

No. of episodes

9.2(8.8);n = 46

12.5(10.2);n = 54

<0.0001***

15.6(11.1);n = 6

9.0(5.0);n = 8

<0.0001***

Hospital stay, days

28.7(29.3);n = 46

43.6(54.6);n = 54

<0.0001***

30.4(27.5);n = 6

23.4(25.5);n = 8

<0.0001***

Atrial flutter (N = 6)

Atrial flutter (N = 2)

Average readmission interval between episodes, days

190.2(175.8);n = 5

42.5(47.1);n = 6

<0.0001***

-

-

-

No. of episodes

3.8(2.2);n = 5

11.5(7.8);n = 6

<0.0001***

-

-

-

Hospital stay, days

28.0(32.5);n = 5

33.3(22.1);n = 6

<0.0001***

-

-

-

  1. * for p≤ 0.05, ** for p ≤ 0.01, *** for p ≤ 0.001; PD-1: Programmed death 1 inhibitors; PD-L1: programmed death 1 ligand inhibitors