Table 1 Characteristics of patients with orthostatic hypotension after CART hospitalization

n

42

9

33

Patient Characteristics

  Age (mean (SD))

63.26 (14.99)

49.33 (19.64)

67.06 (11.05)

0.001

  Sex (%)

0.575

    Male

27 (64.3)

7 (77.8)

20 (60.6)

    Female

15 (35.7)

2 (22.2)

13 (39.4)

  Race (%)

1

    White

41 (97.6)

9 (100.0)

32 (97.0)

    Black

1 (2.4)

0 (0.0)

1 (3.0)

  BMI (mean (SD))

28.83 (5.80)

32.24 (6.76)

27.90 (5.25)

0.045

Past Medical History

  Hypertension (%)

21 (50.0)

4 (44.4)

17 (51.5)

1

  Hyperlipidemia (%)

19 (45.2)

1 (11.1)

18 (54.5)

0.052

  Type 2 Diabetes Mellitus (%)

5 (11.9)

2 (22.2)

3 (9.1)

0.619

  Coronary artery disease (%)

2 (4.8)

1 (11.1)

1 (3.0)

0.9

  Chronic kidney disease (%)

8 (19.0)

0 (0.0)

8 (24.2)

0.245

  Myocardial infarction (%)

1 (2.4)

0 (0.0)

1 (3.0)

1

  Atrial Fibrillation (%)

2 (4.8)

0 (0.0)

2 (6.1)

1

  Tobacco Use (%)

24 (57.1)

4 (44.4)

20 (60.6)

0.625

  Orthostatic hypotension (%)

9 (21.4)

2 (22.2)

7 (21.2)

1

  Neuropathy (%)

26 (61.9)

5 (55.6)

21 (63.6)

0.711

Oncologic History

  Cancer type (%)

    ALL

2 (4.8)

2 (22.2)

0 (0.0)

    DLBCL

39 (92.9)

6 (66.7)

33 (100.0)

    DLBCL/CHL

1 (2.4)

1 (11.1)

0 (0.0)

  CAR-T Product (%)

0.058

    YESCARTA

40 (95.2)

7 (77.8)

33 (100.0)

    KYMRIAH

2 (4.8)

2 (22.2)

0 (0.0)

  Chest/axillary radiation (%)

10 (23.8)

1 (11.1)

9 (27.3)

0.57

  Neck radiation (%)

6 (14.3)

1 (11.1)

5 (15.2)

1

  Stem cell transplant (%)

9 (21.4)

2 (22.2)

7 (21.2)

1

  R-CHOP (%)

27 (64.3)

3 (33.3)

24 (72.7)

0.073

  R-ICE (%)

18 (42.9)

3 (33.3)

15 (45.5)

0.786

  GEM-OX (%)

13 (31.0)

2 (22.2)

11 (33.3)

0.816

  R-EPOCH (%)

9 (21.4)

4 (44.4)

5 (15.2)

0.15

Pre-CART vital signs

  Ambulatory mean SBP (mean (SD))

119.93 (12.31)

125.30 (4.18)

118.46 (13.39)

0.142

  Ambulatory mean DBP (mean (SD))

73.21 (7.45)

78.70 (2.27)

71.71 (7.68)

0.011

  Ambulatory mean HR (mean (SD))

84.18 (13.23)

88.00 (12.24)

83.14 (13.48)

0.335

  Pre-CART orthostatic vital signs assessed (%)

16 (38.1)

5 (55.6)

11 (33.3)

0.407

  Pre-CART orthostatic vital signs positive (%)^a

8 (50.0)

2 (40.0)

6 (54.5)

1

CART Hospitalization

  CART hospitalization time (mean (SD))

18.86 (13.71)

23.67 (24.72)

17.55 (8.93)

0.24

  Time from CART infusion to discharge (mean (SD))

15.38 (9.80)

19.89 (16.72)

14.15 (6.78)

0.121

  Orthostatic vitals assessed (%)

36 (85.7)

8 (88.9)

28 (84.8)

1

  Orthostatic vital signs positive (%)^a

33 (91.7)

7 (87.5)

26 (92.9)

1

Post-CART vital signs

  Discharge orthostatic vital signs assessed (%)

33 (78.6)

8 (88.9)

25 (75.8)

0.694

  Discharge orthostatic vital signs positive (%)^a

18 (54.5)

3 (37.5)

15 (60.0)

0.481

  1 month orthostatic vital signs assessed (%)

36 (85.7)

8 (88.9)

28 (84.8)

1

  1 month orthostatic vital signs positive (%)^a

13 (36.1)

0 (0.0)

13 (46.4)

0.046

  3 months orthostatic vital signs assessed (%)

13 (31.0)

2 (22.2)

11 (33.3)

0.816

  3 months orthostatic vital signs positive (%)^a

3 (23.1)

0 (0.0)

3 (27.3)

1

  Discharge HR (mean (SD))

85.69 (15.43)

88.11 (14.01)

85.03 (15.93)

0.602

  1 month HR (mean (SD))

84.50 (14.55)

85.50 (10.39)

84.23 (15.61)

0.83

  3 months HR (mean (SD))

83.12 (13.47)

79.62 (11.10)

84.19 (14.13)

0.41

CART side effects

  CRS (%)

38 (90.5)

8 (88.9)

30 (90.9)

1

  CRS Grade (%)

0.043

    1

14 (33.3)

6 (66.7)

8 (24.2)

    2

24 (57.1)

2 (22.2)

22 (66.7)

  Tocilizumab (%)

36 (85.7)

7 (77.8)

29 (87.9)

0.818

  Neurotoxicity (%)

24 (57.1)

3 (33.3)

21 (63.6)

0.212

  Neurotoxicity grade (%)

0.177

    1

6 (14.3)

2 (22.2)

4 (12.1)

    2

11 (26.2)

1 (11.1)

10 (30.3)

    3

7 (16.7)

0 (0.0)

7 (21.2)

  Steroids (%)

25 (59.5)

3 (33.3)

22 (66.7)

0.155

Echo parameters

  Pre-CART ejection fraction (mean (SD)) n = 37

54.68 (5.51)

53.11 (4.83)

55.18 (5.70)

0.334

  Pre-CART global longitudinal strain (mean (SD)) n = 18

17.21 (3.10)

-14.60 (2.69)

-17.73 (2.98)

0.112

  Post-CART ejection fraction (mean (SD)) n = 25

53.44 (6.51)

54.00 (5.81)

53.18 (6.98)

0.775

  Post-CART global longitudinal strain (mean (SD)) n = 14

16.52 (3.25)

-16.37 (0.59)

-16.56 (3.69)

0.93

Labs

  Positive troponin (%)

1 (2.4)

0 (0.0)

1 (3.0)

0.558

  Negative troponin (%)

9 (21.4)

3 (33.3)

6 (18.2)

  Troponin not measured (%)

32 (76.2)

6 (66.7)

26 (78.8)

  Pre-CART creatinine (mean (SD))

0.97 (0.52)

0.90 (0.32)

0.99 (0.57)

0.637

  Peak creatinine (mean (SD))

1.24 (0.62)

1.31 (0.58)

1.22 (0.63)

0.703

  Pre-CART HsCRP (mean (SD))

7.02 (6.59)

5.01 (4.57)

7.56 (7.00)

0.309

  Peak HsCRP (mean (SD))

13.96 (8.50)

12.53 (8.80)

14.36 (8.51)

0.574

  Pre-conditioning hemoglobin (mean (SD))

10.10 (1.58)

10.72 (2.56)

9.93 (1.19)

0.187

  CART discharge hemoglobin (mean (SD))

9.60 (1.09)

9.72 (1.16)

9.57 (1.09)

0.72