Table 2 Medications in patients with orthostatic hypotension and CART therapy
From: CD-19 CART therapy and orthostatic hypotension: a single center retrospective cohort study
Cohort (%) | No orthostatic hypotension (%) | Orthostatic hypotension (%) | p-value | |
|---|---|---|---|---|
n | 42 | 9 | 33 | |
Pre-CART | ||||
Beta blocker | 7 (16.7) | 2 (22.2) | 5 (15.2) | 0.631 |
ACEI/ARB | 6 (14.3) | 2 (22.2) | 4 (12.1) | 0.593 |
CCB | 4 (9.5) | 0 (0.0) | 4 (12.1) | 0.561 |
Thiazide diuretic | 3 (7.1) | 1 (11.1) | 2 (6.1) | 0.525 |
Loop diuretic | 2 (4.8) | 1 (11.1) | 1 (3.0) | 0.387 |
Arterial vasodilator | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
Anti-depressants | 6 (14.3) | 1 (11.1) | 5 (15.2) | 1 |
Neuroleptics | 4 (9.5) | 1 (11.1) | 3 (9.1) | 1 |
Alpha-1 blockers | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
Midodrine | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 |
Fludrocortisone | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
CART discharge | ||||
Beta blocker | 9 (21.4) | 3 (33.3) | 6 (18.2) | 0.375 |
ACEI/ARB | 2 (4.8) | 0 (0.0) | 2 (6.1) | 1 |
CCB | 4 (9.5) | 0 (0.0) | 4 (12.1) | 0.561 |
Thiazide diuretic | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
Loop diuretic | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
Arterial vasodilator | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
Anti-depressants | 10 (23.8) | 1 (11.1) | 9 (27.3) | 0.416 |
Neuroleptics | 2 (4.8) | 1 (11.1) | 1 (3.0) | 0.387 |
Alpha-1 blockers | 4 (9.5) | 0 (0.0) | 4 (12.1) | 0.561 |
Midodrine | 2 (4.8) | 0 (0.0) | 2 (6.1) | 1 |
Fludrocortisone | 2 (4.8) | 0 (0.0) | 2 (6.1) | 1 |
1 month post-CART | ||||
Beta blocker | 6 (14.3) | 2 (22.2) | 4 (12.1) | 0.593 |
ACEI/ARB | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
CCB | 3 (7.1) | 0 (0.0) | 3 (9.1) | 1 |
Thiazide diuretic | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 |
Loop diuretic | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
Arterial vasodilator | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 |
Anti-depressants | 9 (21.4) | 1 (11.1) | 8 (24.2) | 0.655 |
Neuroleptics | 3 (7.1) | 1 (11.1) | 2 (6.1) | 0.525 |
Alpha-1 blockers | 4 (9.5) | 0 (0.0) | 4 (12.1) | 0.561 |
Midodrine | 6 (14.3) | 0 (0.0) | 6 (18.2) | 0.312 |
Fludrocortisone | 5 (11.9) | 0 (0.0) | 5 (15.2) | 0.567 |
3 months post-CART | ||||
Beta blocker | 7 (16.7) | 3 (33.3) | 4 (12.1) | 0.155 |
ACEI/ARB | 2 (4.8) | 0 (0.0) | 2 (6.1) | 1 |
CCB | 2 (4.8) | 0 (0.0) | 2 (6.1) | 1 |
Thiazide diuretic | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 |
Loop diuretic | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
Arterial vasodilator | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 |
Anti-depressants | 10 (23.8) | 1 (11.1) | 9 (27.3) | 0.416 |
Neuroleptics | 3 (7.1) | 0 (0.0) | 3 (9.1) | 1 |
Alpha-1 blockers | 1 (2.4) | 0 (0.0) | 1 (3.0) | 1 |
Midodrine | 4 (9.5) | 0 (0.0) | 4 (12.1) | 0.561 |
Fludrocortisone | 7 (16.7) | 0 (0.0) | 7 (21.2) | 0.314 |