Fig. 4

Clinical relevance of the hypertension-related genes. A Correlation between hypertension-related genes and clinically actionable genes (CAGs). Pearson’s correlation coefficient |R|> 0.3, P < 0.05. Red and blue boxes represent positive and negative correlation, respectively. Color scale represents the magnitude of Pearson’s correlation coefficient. The white boxes indicate the cancer type number is less than five. The “ × ” represents the protein–protein interactions (PPIs) of hypertension-related genes and CAGs based on the data from HPRD. B Clinical relevance of the hypertension-related genes across 33 cancer types. Yellow boxes indicate differently expressed hypertension-related genes in cancer. The up and down arrows represent the upregulation and downregulation of genes in later stages (III/IV) compared with early stages (I/II) (fold change > 1.5). Yellow (1) represent differentially expressed genes (DEGs), and Grey (0) represent non-DEGs. The red and blue boxes indicate high and low expression, respectively, in tumors associated with worse overall survival (log rank test FDR < 0.05)