Table 2 Cardiac health measures among 80 childhood and young adult cancer survivors with low left ventricular ejection fraction
Test | N (%) | LVEF 50–54.9% N = 38 (47.5%) | LVEF 41–49.9% N = 18 (25.0%) | LVEF < 41% N = 24 (30.0%) | P-valuea |
|---|---|---|---|---|---|
Fractional shortening (%) | < 0.001 | ||||
> 25 | 37 (46.3) | 31 (81.6) | 3 (16.7) | 3 (12.5) | |
20–25 | 16 (20.0) | 2 (5.3) | 9 (50.0) | 5 (20.8) | |
< 20 | 6 (7.5) | 0 (0.0) | 0 (0.0) | 6 (25.0) | |
Missing | 21 (26.3) | 5 (13.2) | 6 (33.3) | 10 (41.7) | |
Left ventricular hypertrophy | 8 (10.0) | 1 (2.6) | 1 (5.6) | 6 (25.0) | 0.013 |
Left atrial enlargement | 7 (8.8) | 1 (2.6) | 0 (0.0) | 6 (25.0) | 0.003 |
Valvular disease | |||||
Mitral regurgitation | 24 (30.0) | 5 (13.2) | 4 (22.2) | 15 (62.5) | < 0.001 |
Tricuspid regurgitation | 28 (35.0) | 8 (21.1) | 6 (33.3) | 14 (58.3) | 0.011 |
Aortic regurgitation | 9 (11.3) | 0 (0.0) | 3 (16.7) | 6 (25.0) | 0.007 |
Pulmonic regurgitation | 13 (16.3) | 6 (15.8) | 1 (5.6) | 6 (25.0) | 0.238 |
Mitral stenosis | 2 (2.5) | 1 (2.6) | 0 (0.0) | 1 (4.2) | 0.692 |
Aortic stenosis | 6 (7.5) | 2 (5.3) | 2 (11.1) | 2 (8.3) | 0.727 |
Symptomatic at lowest ejection fraction | 23 (28.8) | 8 (21.1) | 5 (27.8) | 10 (41.7) | 0.216 |
Coronary artery disease | 21 (26.3) | 7 (18.4) | 3 (16.7) | 11 (45.8) | 0.033 |
Congestive heart failure | 14 (17.5) | 1 (2.6) | 3 (16.7) | 10 (41.7) | < 0.001 |
Myocardial infarction | 7 (8.8) | 1 (2.6) | 2 (11.1) | 4 (16.7) | 0.150 |
Cardiac-related death | 2 (2.5) | 1 (2.6) | 1 (5.6) | 0 (0.0) | 0.600 |