Skip to main content

Table 3 Supporting evidence for the informative microRNA’s from clinical studies of cardiovascular disorders, indicating the sample type, methodology, cardiovascular condition and the direction of miRNA expression

From: A systematic review of miRNAs as biomarkers for chemotherapy-induced cardiotoxicity in breast cancer patients reveals potentially clinically informative panels as well as key challenges in miRNA research

miRNA

Reference

Sample Type

Evaluation Method

Cardiovascular condition

Expression Change to controls

miR-1-3p

[36]

Plasma

qPCR

Acute myocardial infarction

Increased

[37]

Serum + urine

qPCR

Acute myocardial infarction

Increased

[38]

Plasma

NGS

Acute myocardial infarction

Increased

[39]

Plasma

qPCR

Acute myocardial infarction

Increased

[40]

Plasma

qPCR

Acute myocardial infarction

Increased

[41]

Plasma

qPCR

Acute myocardial infarction

Increased

[42]

FFPE myocardial tissue

qPCR

Sudden cardiac death

Increased

[43]

Plasma

NGS + qPCR

Failed myocardial reperfusion

Increased

[44]

PBMC

qPCR

Acute viral myocarditis

Increased

[45]

Plasma

qPCR

Hypertrophic cardiomyopathy

Increased

[46]

Cardiac tissue

qPCR

Hypertrophic cardiomyopathy

Decreased

[47]

Endomyocardial biopsies

qPCR + microarray

Dilated cardiomyopathies

Increased

[48]

Serum

qPCR

Transcoronary ablation of septal hypertrophy (TASH)

Increased

[49]

Myocardial tissue

NGS

Tetralogy of Fallot

Decreased

[50]

Plasma

qPCR

Takotsubo cardiomyopathy

Increased

[51]

PBMC

qPCR

Hypertensive heart disease

Increased

[52]

Plasma

qPCR

Non-ST elevation myocardial infarction (NSTEMI)

Increased

[53]

Plasma

qPCR

Acute coronary syndrome

Increased

[54]

Right arterial appendage biopsies + Plasma

qPCR

Atrial fibrillation

Increased

[55]

Myocardial tissue

qPCR + miRNA array

Atrial fibrillation

Increased

[56]

Myocardial tissue

qPCR

Heart failure

Decreased

[57]

Serum

qPCR

Heart failure

Decreased

[58]

Plasma

qPCR

Acute heart failure

Decreased

miR-17-5p

[59]

Plasma

qPCR

Acute coronary syndrome

Increased

[60]

Plasma

dPCR

Coronary artery disease

Increased

[61]

Plasma

qPCR

Heart failure

Decreased

[62]

Plasma

qPCR

Hypertrophic cardiomyopathy

Increased

[63]

Whole blood

qPCR

Bicuspid aortic valve disorder

Decreased

miR-19a

[64]

Lung tissue

microarray

Pulmonary arterial hypertension

Increased

[65]

Serum

qPCR

Acute coronary syndrome

Increased

[66]

Serum

microarray

Atherosclerosis

Increased

miR-29a-3p

[67]

Ascending aorta tissue

qPCR

Bicuspid aortic valve disorders

Decreased

[68]

Serum

qPCR

Hypertrophic cardiomyopathy

Increased

[69]

Serum

qPCR

Hypertrophic cardiomyopathy

Increased

[62]

Plasma

qPCR

Hypertrophic cardiomyopathy

Increased

[70]

Plasma

NGS + FirePlex assay

Coronary heart disease

Increased

[71]

Plasma

qPCR

Coronary heart disease

Increased

[72]

Cardiac valve tissue

qPCR

Valvular heart disease

Decreased

[73]

Plasma

qPCR

Cardiac fibrosis

Increased

[74]

Plasma

qPCR

Left ventricular remodelling

Increased

[75]

Plasma

qPCR

Pulmonary arterial hypertension

Increased

miR-34a-5p

[76]

Plasma

qPCR

Chronic heart disease

Increased

[77]

Whole blood

qPCR

Cardiac aging

Increased

[78]

Plasma

qPCR

Left ventricular (LV) remodelling

Increased

[79]

Plasma

qPCR

Left ventricular dysfunction

Increased

[80]

Plasma

qPCR

Heart failure

Increased

[81]

Serum

qPCR

Acute myocardial infarction

Increased

[82]

Serum

qPCR

Arterial fibrillation

Increased

miR-122-5p

[83]

Serum

qPCR

Coronary artery disease

Increased

[84]

Plasma

microarray + qPCR

Acute coronary syndrome

Increased

[85]

Plasma

qPCR

Cardiogenic shock

Increased

[86]

Whole blood

qPCR

Cardiogenic shock

Increased

[87]

Plasma

qPCR

Ventricular fibrillation sudden cardiac arrest

Increased

[88]

Plasma

qPCR

Chronic systolic heart failure

Increased

[89]

Plasma

microarray

Aortic valve dysfunction

Decreased

[90]

Ascending aorta tissue + plasma

qPCR

Bicuspid aortic valve disease

Decreased

[91]

Myocardial tissue

NGS + qPCR

Arrythmogenic cardiomyopathy

Increased

[92]

Serum

qPCR

Acute myocardial infarction

Increased

[93]

Serum

microarray

Congestive heart failure

Increased

miR-130a

[59]

Plasma

qPCR

Acute coronary syndrome

Increased

[94]

Plasma

qPCR

Peripartum cardiomyopathy

Increased

[95]

Whole blood

microarray

Pulmonary hypertension

Increased

[96]

Plasma

qPCR

Coronary heart disease

Decreased

[89]

Plasma

microarray

Aortic valve dysfunction

Increased

miR-199a-3p

[97]

Plasma

qPCR

Acute heart failure

Decreased

[98]

Right arterial appendage biopsies

qPCR

Postoperative atrial fibrillation

Decreased

[99]

Plasma

qPCR

Coronary heart disease

Decreased

[100]

Right arterial appendage biopsies

qPCR

Coronary heart disease

Decreased

[101]

Plasma

qPCR

Stable coronary artery disease

Decreased

[102]

Plasma

qPCR

Peripheral arterial disease

Decreased

[103]

Plasma

microarray + qPCR

Atrial fibrillation in HFrEF patients

Increased

[104]

Plasma

NGS

Acute myocardial infarction

Increased

miR-378

[105]

Plasma

qPCR

Coronary heart disease

Decreased

[106]

Whole blood

microarray + qPCR

Coronary artery disease

Decreased

miR-423

[107]

Plasma

qPCR

Acute myocardial infarction

Increased

[108]

Plasma

qPCR

Dilated cardiomyopathy

Increased

[109]

Plasma

microarray

Heart failure

Increased

[58]

Plasma

qPCR

Acute heart failure

Decreased

[110]

Plasma

qPCR

Acute heart failure

Increased

[111]

Serum

qPCR

Coronary artery disease

Decreased

[38]

Plasma

NGS

Acute myocardial infarction

Increased

[112]

Plasma

qPCR

Acute myocardial infarction

Increased

[113]

Plasma

qPCR

Cardiogenic shock

Increased

[114]

Plasma

qPCR

Left ventricular remodelling

Increased

[115]

Serum

qPCR

Left ventricular remodelling

Increased

[116]

Whole blood

microarray + qPCR

Transposition of the great arteries

Increased

[117]

Serum

qPCR

Heart failure

Increased

[80]

Plasma

qPCR

Heart failure

Increased

miR-499

[38]

Plasma

NGS

Acute myocardial infarction

Increased

[41]

Plasma

qPCR

Acute myocardial infarction

Increased

[118]

Plasma

qPCR

Acute myocardial infarction

Increased

[119]

Whole blood

qPCR

Acute myocardial infarction

Increased

[120]

Serum

dPCR+qPCR

Stable coronary artery disease

Increased

[40]

Plasma

qPCR

Acute coronary syndrome

Increased

[121]

Plasma

qPCR

Acute coronary syndrome

Increased

[115]

Serum

qPCR

ST-segment-elevation myocardial infarction (STEMI)

Increased

[52]

Plasma

qPCR

Non-ST elevation myocardial infarction (NSTEMI)

Increased

[122]

Endomyocardial biopsies

qPCR

Dilated cardiomyopathy

Increased

[123]

PBMC

qPCR

Heart failure with preserved ejection fraction (HFpEF)

Increased

[42]

FFPE myocardial tissue

qPCR

Sudden cardiac death

Increased

[83]

Serum

qPCR

Unstable coronary artery disease

Increased

miR-885-5p

   

No relevant associations

 

miR-1273 g-3p

   

No relevant associations

–

miR-4638-3p

   

No relevant associations

–

  1. PBMC Peripheral blood mononuclear cells, FFPE Formalin-fixed paraffin-embedded tissue, NGS Next generation sequencing, qPCR Quantitative polymerase chain reaction, dPCR Digital polymerase chain reaction