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Table 3 Supporting evidence for the informative microRNA’s from clinical studies of cardiovascular disorders, indicating the sample type, methodology, cardiovascular condition and the direction of miRNA expression

From: A systematic review of miRNAs as biomarkers for chemotherapy-induced cardiotoxicity in breast cancer patients reveals potentially clinically informative panels as well as key challenges in miRNA research

miRNA Reference Sample Type Evaluation Method Cardiovascular condition Expression Change to controls
miR-1-3p [36] Plasma qPCR Acute myocardial infarction Increased
[37] Serum + urine qPCR Acute myocardial infarction Increased
[38] Plasma NGS Acute myocardial infarction Increased
[39] Plasma qPCR Acute myocardial infarction Increased
[40] Plasma qPCR Acute myocardial infarction Increased
[41] Plasma qPCR Acute myocardial infarction Increased
[42] FFPE myocardial tissue qPCR Sudden cardiac death Increased
[43] Plasma NGS + qPCR Failed myocardial reperfusion Increased
[44] PBMC qPCR Acute viral myocarditis Increased
[45] Plasma qPCR Hypertrophic cardiomyopathy Increased
[46] Cardiac tissue qPCR Hypertrophic cardiomyopathy Decreased
[47] Endomyocardial biopsies qPCR + microarray Dilated cardiomyopathies Increased
[48] Serum qPCR Transcoronary ablation of septal hypertrophy (TASH) Increased
[49] Myocardial tissue NGS Tetralogy of Fallot Decreased
[50] Plasma qPCR Takotsubo cardiomyopathy Increased
[51] PBMC qPCR Hypertensive heart disease Increased
[52] Plasma qPCR Non-ST elevation myocardial infarction (NSTEMI) Increased
[53] Plasma qPCR Acute coronary syndrome Increased
[54] Right arterial appendage biopsies + Plasma qPCR Atrial fibrillation Increased
[55] Myocardial tissue qPCR + miRNA array Atrial fibrillation Increased
[56] Myocardial tissue qPCR Heart failure Decreased
[57] Serum qPCR Heart failure Decreased
[58] Plasma qPCR Acute heart failure Decreased
miR-17-5p [59] Plasma qPCR Acute coronary syndrome Increased
[60] Plasma dPCR Coronary artery disease Increased
[61] Plasma qPCR Heart failure Decreased
[62] Plasma qPCR Hypertrophic cardiomyopathy Increased
[63] Whole blood qPCR Bicuspid aortic valve disorder Decreased
miR-19a [64] Lung tissue microarray Pulmonary arterial hypertension Increased
[65] Serum qPCR Acute coronary syndrome Increased
[66] Serum microarray Atherosclerosis Increased
miR-29a-3p [67] Ascending aorta tissue qPCR Bicuspid aortic valve disorders Decreased
[68] Serum qPCR Hypertrophic cardiomyopathy Increased
[69] Serum qPCR Hypertrophic cardiomyopathy Increased
[62] Plasma qPCR Hypertrophic cardiomyopathy Increased
[70] Plasma NGS + FirePlex assay Coronary heart disease Increased
[71] Plasma qPCR Coronary heart disease Increased
[72] Cardiac valve tissue qPCR Valvular heart disease Decreased
[73] Plasma qPCR Cardiac fibrosis Increased
[74] Plasma qPCR Left ventricular remodelling Increased
[75] Plasma qPCR Pulmonary arterial hypertension Increased
miR-34a-5p [76] Plasma qPCR Chronic heart disease Increased
[77] Whole blood qPCR Cardiac aging Increased
[78] Plasma qPCR Left ventricular (LV) remodelling Increased
[79] Plasma qPCR Left ventricular dysfunction Increased
[80] Plasma qPCR Heart failure Increased
[81] Serum qPCR Acute myocardial infarction Increased
[82] Serum qPCR Arterial fibrillation Increased
miR-122-5p [83] Serum qPCR Coronary artery disease Increased
[84] Plasma microarray + qPCR Acute coronary syndrome Increased
[85] Plasma qPCR Cardiogenic shock Increased
[86] Whole blood qPCR Cardiogenic shock Increased
[87] Plasma qPCR Ventricular fibrillation sudden cardiac arrest Increased
[88] Plasma qPCR Chronic systolic heart failure Increased
[89] Plasma microarray Aortic valve dysfunction Decreased
[90] Ascending aorta tissue + plasma qPCR Bicuspid aortic valve disease Decreased
[91] Myocardial tissue NGS + qPCR Arrythmogenic cardiomyopathy Increased
[92] Serum qPCR Acute myocardial infarction Increased
[93] Serum microarray Congestive heart failure Increased
miR-130a [59] Plasma qPCR Acute coronary syndrome Increased
[94] Plasma qPCR Peripartum cardiomyopathy Increased
[95] Whole blood microarray Pulmonary hypertension Increased
[96] Plasma qPCR Coronary heart disease Decreased
[89] Plasma microarray Aortic valve dysfunction Increased
miR-199a-3p [97] Plasma qPCR Acute heart failure Decreased
[98] Right arterial appendage biopsies qPCR Postoperative atrial fibrillation Decreased
[99] Plasma qPCR Coronary heart disease Decreased
[100] Right arterial appendage biopsies qPCR Coronary heart disease Decreased
[101] Plasma qPCR Stable coronary artery disease Decreased
[102] Plasma qPCR Peripheral arterial disease Decreased
[103] Plasma microarray + qPCR Atrial fibrillation in HFrEF patients Increased
[104] Plasma NGS Acute myocardial infarction Increased
miR-378 [105] Plasma qPCR Coronary heart disease Decreased
[106] Whole blood microarray + qPCR Coronary artery disease Decreased
miR-423 [107] Plasma qPCR Acute myocardial infarction Increased
[108] Plasma qPCR Dilated cardiomyopathy Increased
[109] Plasma microarray Heart failure Increased
[58] Plasma qPCR Acute heart failure Decreased
[110] Plasma qPCR Acute heart failure Increased
[111] Serum qPCR Coronary artery disease Decreased
[38] Plasma NGS Acute myocardial infarction Increased
[112] Plasma qPCR Acute myocardial infarction Increased
[113] Plasma qPCR Cardiogenic shock Increased
[114] Plasma qPCR Left ventricular remodelling Increased
[115] Serum qPCR Left ventricular remodelling Increased
[116] Whole blood microarray + qPCR Transposition of the great arteries Increased
[117] Serum qPCR Heart failure Increased
[80] Plasma qPCR Heart failure Increased
miR-499 [38] Plasma NGS Acute myocardial infarction Increased
[41] Plasma qPCR Acute myocardial infarction Increased
[118] Plasma qPCR Acute myocardial infarction Increased
[119] Whole blood qPCR Acute myocardial infarction Increased
[120] Serum dPCR+qPCR Stable coronary artery disease Increased
[40] Plasma qPCR Acute coronary syndrome Increased
[121] Plasma qPCR Acute coronary syndrome Increased
[115] Serum qPCR ST-segment-elevation myocardial infarction (STEMI) Increased
[52] Plasma qPCR Non-ST elevation myocardial infarction (NSTEMI) Increased
[122] Endomyocardial biopsies qPCR Dilated cardiomyopathy Increased
[123] PBMC qPCR Heart failure with preserved ejection fraction (HFpEF) Increased
[42] FFPE myocardial tissue qPCR Sudden cardiac death Increased
[83] Serum qPCR Unstable coronary artery disease Increased
miR-885-5p     No relevant associations  
miR-1273 g-3p     No relevant associations
miR-4638-3p     No relevant associations
  1. PBMC Peripheral blood mononuclear cells, FFPE Formalin-fixed paraffin-embedded tissue, NGS Next generation sequencing, qPCR Quantitative polymerase chain reaction, dPCR Digital polymerase chain reaction