Fig. 1

In this young cohort of adults with congenital heart disease and cancer, only a minority of cancers were detected by screening. Despite predominantly moderate or great anatomic complexity, most deaths occurred to cardiovascular causes. Baseline arrhythmia, diuretic requirement and advanced cancer predicted mortality. A high incidence of MACCE was observed, with baseline diuretic therapy being the only independent risk factor. Rates of therapy-related MACCE and consequent cessation of cancer therapy were low. Created with biorender.com