From: Mechanisms of trastuzumab induced cardiotoxicity – is exercise a potential treatment?
Reference | Patient Group | Intervention | Finding |
---|---|---|---|
Kirkham et al., 2018 [62] | 24 patients received (intervention group = 13) 60 mg/m2 of Dox and 600 mg/m2 of cyclophosphamide | 24-48 h before each patient’s first doxorubicin treatment Supervised treadmill bout involving 10-min warm-up, 30 min (70% age-predicted HRR), 5 min cooldown | No difference in longitudinal strain, twist or cardiac troponin Mitigated increase in cardiac output, resting heart rate and decreased systemic vascular resistance relative to control group |
Lee et al., 2019 [63] | 30 participants (intervention group = 15) following completion of 8-week anthracycline-based chemotherapy (every 2-weeks for 4 cycles) | 3x weekly for 8 weeks HIIT sessions included 7 × (1-min interval 90% peak power output (PPO) followed by 2 min interval at 10% PPO) | VO2-max maintained in HIIT groups compared with significant decrease in control group |
Mijwel et al., 2018 [64] | 59 participants scheduled to undergo chemotherapy consisting of anthracyclines Resistance training (RT) group = 30 Aerobic training (AT) group = 27 | 2x weekly, 16 weeks RT = 2–3 sets of 8–12 reps at 80% of 1-rep-max AT = 20 min of moderate-intensity continuous aerobic exercise | RT and AT significantly attenuated the fall in predicted VO2peak seen in control groups |
Ma, 2018 [65] | 70 participants (intervention group = 31) undergoing anthracycline-containing therapy | Aerobic exercise 3x weekly for 16 weeks | Significant attenuation of LVEF decline in exercise group relative to control group |
Foulkes et al., 2022 [54] | 104 participants (intervention group = 52) 60 mg/m2 doxorubicin combined with 600 mg/m2 cyclophosphamide for 4 cycles (3 months) | 3-4x weekly for 12 months Broken into 3 phases with decreasing levels of supervision Progressive loading/de-loading of volume in line with chemotherapy cycles Sessions consisted of varying combinations of moderate-intensity endurance training (30-60 min at heart rate [HR] 5–30 b/min below ventilatory threshold) ), tempo training (35 min at HR within 10 b/min of VT), high intensity interval training (4 × 2–4 min at > 85% maximal HR), and moderate-to-high intensity resistance training (2 sets x 8–15 repetitions at load equivalent to 60–85% of 1-repetition max) | Exercise associated with a net + 3.5 mL/kg/min improvement in VO2 peak Significantly greater improvements in cardiac reserve measures (change in CO, SV, LVEF and RVEF from rest to peak exercise) |