Skip to main content

Table 6 Strain changes in RT-induced MCT studies using MRI (No increase of strain was reported)

From: Quantitative assessment of radiotherapy-induced myocardial damage using MRI: a systematic review

Study

Patients

Cancer type

Decrease

Constant

Dose-dependent

Van Der Velde et al., [50]

80

HL & NHL

GLS (-19.5±2.5 vs -20.6±2, p=0.01)

GCS (-17.9±2.5 vs -20.4±2.2, P<0.001)

GRS (69±15 vs 76±15, p=0.02) at 20 years post-RT.

-

-

Vallabhaneni et al., [54]

11

Lung, breast, lymphoma

-

GLS: No significant % changes in patients with higher radiation (-15.2±15.2%) or patients with minimal radiation (-6.8±3.1%)

GCS: No significant % changes in patients with higher radiation

(-8.4±14.5%) or patients with minimal radiation (-4.0±6.9%)

at 6-months following RT.

-

Bergom et al., [48]

20

Breast

Abnormal lower absolute strain values in

16/20 patients -14.6% (-17.8% to -11.1%) compared to normal range -22.1% to -15.9% at 8.3 years post-RT

-

-

Tahir et al., [55]

66

Breast

In epirubicin-chemotherapy-based

followed by RT group:

GLS (baseline: -18±2%,

therapy completion: -17±2%, p=0.01;

13±2 months: -17±2% p=0.01)

GCS (baseline: -18±2%,

therapy completion: -17±3%, p=0.03;

13±2 months: -17±3% p=0.01)

In epirubicin-chemotherapy-based

followed by RT group: GRS changes were not significant

(baseline: 36±7%; post-therapy completion: 34±8%; 13±2 months post-therapy completion: 34±6%)

-

-

In left-sided RT group:

GLS (baseline: -18±2%, therapy completion: -18±2%, 13±2 months post-therapy completion: -18±1%)

GCS (baseline: -18±2%, therapy completion: -18±2%, 13±2 months post-therapy completion: -19±3%)

GRS (baseline: 39±6%, therapy completion: 39±9%, 13±2 months post-therapy completion: 39±7%)

-

Tang et al., [71]

22

Breast

At 6 weeks vs pre-treatment:

3D circumferential: segment 7 -16.39 vs -19.17, segment 8 -18.73 vs -20.67, segment 13 -15.95 vs -18.48.

2D circumferential: segment 1 -19.13 vs -23.57, segment 14 -25.01 vs -28.29.

3D radial: segment 8 25.46 vs 35.32, segment 9 17.54 vs 27.24.

3D longitudinal: segment 7 -19.12 vs -21.44

-

Negative correlation:

3D radial at segment 6 and max dose

(-0.443, p=0.05),

2D radial at segment 14 and max dose

(-0.543, p=0.01),

Positive correlation:

3D longitudinal strain at segment 6 and max dose (0.669, P<0.01).