From: Quantitative assessment of radiotherapy-induced myocardial damage using MRI: a systematic review
Study | Patients | Cancer type | Decrease | Constant | Dose-dependent |
---|---|---|---|---|---|
Van Der Velde et al., [50] | 80 | HL & NHL | GLS (-19.5±2.5 vs -20.6±2, p=0.01) GCS (-17.9±2.5 vs -20.4±2.2, P<0.001) GRS (69±15 vs 76±15, p=0.02) at 20 years post-RT. | - | - |
Vallabhaneni et al., [54] | 11 | Lung, breast, lymphoma | - | GLS: No significant % changes in patients with higher radiation (-15.2±15.2%) or patients with minimal radiation (-6.8±3.1%) GCS: No significant % changes in patients with higher radiation (-8.4±14.5%) or patients with minimal radiation (-4.0±6.9%) at 6-months following RT. | - |
Bergom et al., [48] | 20 | Breast | Abnormal lower absolute strain values in 16/20 patients -14.6% (-17.8% to -11.1%) compared to normal range -22.1% to -15.9% at 8.3 years post-RT | - | - |
Tahir et al., [55] | 66 | Breast | In epirubicin-chemotherapy-based followed by RT group: GLS (baseline: -18±2%, therapy completion: -17±2%, p=0.01; 13±2 months: -17±2% p=0.01) GCS (baseline: -18±2%, therapy completion: -17±3%, p=0.03; 13±2 months: -17±3% p=0.01) | In epirubicin-chemotherapy-based followed by RT group: GRS changes were not significant (baseline: 36±7%; post-therapy completion: 34±8%; 13±2 months post-therapy completion: 34±6%) | - |
- | In left-sided RT group: GLS (baseline: -18±2%, therapy completion: -18±2%, 13±2 months post-therapy completion: -18±1%) GCS (baseline: -18±2%, therapy completion: -18±2%, 13±2 months post-therapy completion: -19±3%) GRS (baseline: 39±6%, therapy completion: 39±9%, 13±2 months post-therapy completion: 39±7%) | - | |||
Tang et al., [71] | 22 | Breast | At 6 weeks vs pre-treatment: 3D circumferential: segment 7 -16.39 vs -19.17, segment 8 -18.73 vs -20.67, segment 13 -15.95 vs -18.48. 2D circumferential: segment 1 -19.13 vs -23.57, segment 14 -25.01 vs -28.29. 3D radial: segment 8 25.46 vs 35.32, segment 9 17.54 vs 27.24. 3D longitudinal: segment 7 -19.12 vs -21.44 | - | Negative correlation: 3D radial at segment 6 and max dose (-0.443, p=0.05), 2D radial at segment 14 and max dose (-0.543, p=0.01), Positive correlation: 3D longitudinal strain at segment 6 and max dose (0.669, P<0.01). |