Table 1 Patient’s Baseline Characterization
n = 451 | Patients not on TKI’s (n = 265) | P-Value | Patients on TKI’s (n = 186) | P-Value | ||
|---|---|---|---|---|---|---|
Non-DM(n = 213) | DM(n = 52) | Non-DM(n = 148) | DM(n = 38) | |||
Age (years) | 62.92 ± 13.22 | 67.18 ± 9.72 | 0.0161 | 58.67 ± 12.95 | 61.81 ± 12.46 | 0.1930 |
Time between Visits (years) | 3.08 ± 3.22 | 2.63 ± 3.21 | 0.3606 | 3.59 ± 3.35 | 3.23 ± 3.08 | 0.5271 |
Gender, n (%) | ||||||
Male | 116 (54.72) | 30 (57.69) | 0.6990 | 70 (48.28) | 26 (68.42) | 0.0269 |
Female | 96 (45.28) | 22 (42.31) | 75 (51.72) | 12 (31.58) | ||
Race, n (%) | ||||||
Caucasian | 186 (88.15) | 42 (80.77) | 0.2134 | 125 (86.81) | 24 (64.86) | 0.0192 |
African American | 12 (5.69) | 5 (9.62) | 8 (5.56) | 6 (16.22) | ||
Asian | 4 (1.90) | 0 (0.0) | 4 (2.78) | 3 (8.11) | ||
Other | 9 (4.27) | 5 (9.62) | 7 (4.86) | 4 (10.81) | ||
Ethnicity, n (%) | ||||||
Non-Hispanic | 196 (95.15) | 48 (94.12) | 0.7258 | 133 (93.66) | 31 (91.18) | 0.7035 |
Hispanic | 10 (4.85) | 3 (5.88) | 9 (6.34) | 3 (8.82) | ||
Obesity, n (%) | ||||||
BMI < 25 | 85 (41.26) | 22 (42.31) | 0.9837 | 61 (44.53) | 12 (31.58) | 0.1442 |
BMI 25–30 | 66 (32.04) | 16 (30.77) | 30 (21.90) | 14 (36.84) | ||
BMI ≥ 30 | 55 (26.70) | 14 (26.92) | 46 (33.58) | 12 (31.58) | ||
BMI | 26.62 ± 6.71 | 26.86 ± 6.47 | 0.8125 | 27.25 ± 7.19 | 28.64 ± 7.50 | 0.3109 |
HbA1c | 5.51 ± 0.53 | 7.40 ± 1.19 | < 0.0001 | 5.41 ± 0.57 | 7.60 ± 1.28 | < 0.0001 |
Hypertension, n(%) | ||||||
No | 99 (46.48) | 23 (4.23) | 0.7706 | 93 (62.84) | 19 (50.0) | 0.1492 |
Yes | 114 (53.52) | 29 (55.77) | 55 (37.16) | 19 (50.0) | ||
Dyslipidemia, n(%) | ||||||
No | 164 (77.0) | 33 (63.46) | 0.0451 | 123 (83.11) | 27 (71.05) | 0.0934 |
Yes | 49 (23.0) | 19 (36.54) | 25 (16.89) | 11 (28.95) | ||
Alcohol Use, n (%) | ||||||
None | 144 (67.61) | 36 (69.23) | 0.8831 | 103 (69.59) | 27 (71.05) | 0.7482 |
Monthly | 28 (13.15) | 6 (11.54) | 14 (9.46) | 2 (5.26) | ||
Weekly | 18 (8.45) | 6 (11.54) | 16 (10.81) | 5 (13.16) | ||
Daily | 9 (4.23) | 1 (1.92) | 1 (0.68) | 1 (2.63) | ||
Abuse | 14 (6.57) | 3 (5.77) | 14 (9.46) | 3 (7.89) | ||
Heart rate (BPM) | 80.59 ± 20.36 | 84.67 ± 19.58 | 0.1849 | 83.26 ± 20.48 | 81.08 ± 20.89 | 0.5671 |
QTc (ms), 1st Visit | 436.31 ± 30.66 | 437.10 ± 35.06 | 0.8817 | 436.70 ± 34.48 | 445.21 ± 36.82 | 0.2035 |
LVEF (%), 1st Visit | 57.64 ± 12.85 | 57.44 ± 13.77 | 0.9329 | 59.13 ± 12.22 | 58.72 ± 10.83 | 0.8568 |
QTC (ms), 2nd Visit | 471.89 ± 44.62 | 477.71 ± 53.25 | 0.4686 | 473.46 ± 53.99 | 474.29 ± 40.34 | 0.9167 |
LVEF(%), 2nd Visit | 55.11 ± 15.21 | 45.50 ± 20.51 | 0.6263 | 60.23 ± 14.12 | 56.00 ± 27.07 | 0.8137 |