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Table 2 Cardiac Events Induced by TKIs in Patients with QTc Prolongation

From: The association of QTc prolongation with cardiovascular events in cancer patients taking tyrosine kinase inhibitors (TKIs)

Incidences of events

Non-TKI (n = 265)

TKI (n = 186)

QTC <450, n (%)

QTC 450–479, n (%)

QTC 480–499, n(%)

QTC  ≥500, n (%)

QTC ≥450 all, n (%)

1st

2nd

P Value

1st

2nd

P Value

1st

2nd

P Value

1st

2nd

P Value

1st

2nd

P Value

MI, n (%)

                 

No

184 (69.43)

141 (75.8)

102 (81.60)

59 (85.51)

0.003

27 (64.29)

33 (67.35)

0.759

9

(75.0)

18 (78.26)

0.827

3

(42.86)

31 (68.89)

0.178

92 (63.89)

195 (66.10)

0.647

Yes

81 (30.57)

45

(24.19)

23 (18.40)

10 (14.49)

0.003

15 (35.71)

16 (32.65)

0.759

3

(25.0)

5 (21.74)

0.827

4

(57.14)

14 (31.11)

0.178

52 (36.11)

100 (33.90)

0.647

HF, n (%)

                 

No

194 (73.21)

148

(79.57)

105 (84.0)

59 (85.51)

0.015

30 (71.43)

39 (79.59)

0.365

9

(75.0)

18 (78.26)

0.827

4

(57.14)

32 (71.11)

0.456

95 (65.97)

206 (69.83)

0.414

Yes

71 (26.79)

18

(20.43)

20 (16.0)

10 (14.49)

0.015

12 (28.57)

10 (20.41)

0.365

3

(25.0)

5 (21.74)

0.827

3

(42.86)

13 (28.89)

0.456

49 (34.03)

89 (30.17)

0.414

Stroke, n(%)

                 

No

247 (93.21)

177

(95.16)

119 (95.20)

68 (98.55)

0.204

40 (95.24)

45 (91.84)

0.515

12 (100.0)

23 (100.0)

NA

6

(85.71)

41 (91.11)

0.652

135 (93.75)

276 (93.56)

0.939

Yes

18 (6.79)

9

(4.84)

6 (4.80)

1 (1.45)

0.204

2 (4.76)

4 (8.16)

0.515

0

(0.0)

0

(0.0)

NA

1

(14.29)

4 (8.89)

0.652

9 (6.25)

19 (6.44)

0.939

All-Cause Mortality, n(%)

                 

No

168 (63.40)

109

(58.60)

78 (62.40)

51 (73.91)

0.218

21 (50.0)

28 (57.14)

0.496

6 (50.0)

9 (39.13)

0.537

4

(57.14)

21 (46.67)

0.606

83 (57.64)

167 (56.61)

0.838

Yes

97 (36.60)

77

(41.4)

47 (37.60)

18 (26.09)

0.218

21 (50.0)

21 (42.86)

0.496

6 (50.0)

14 (60.87)

0.537

3

(42.86)

24 * (53.33)

0.6058

61 (42.36)

128 (43.39)

0.838

Cardiac Mortality, n(%)

                 

No

262 (98.87)

117

(95.16)

119 (95.20)

68 (98.55)

0.062

39 (92.86)

42 (85.71)

0.277

12 (100.0)

22 (95.65)

1.000

6

(85.71)

44 (97.78)

0.1226

139 (96.53)

284 (96.27)

0.893

Yes

3

(1.13)

10

(5.38)

6

(4.80)

1 (1.45)

0.0619

3 (7.14)

7 (14.29)

0.2774

0 (0.0)

1 (4.35)

1.0000

1

(14.29)

1 (2.22)

0.1226

5

(3.47)

11 (3.73)

0.893

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Cardio-Oncology

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